CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase 
Protein Synonyms/Alias
  
Gene Name
 Jak2 
Gene Synonyms/Alias
 mCG_9104 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
244IQQFSQCKATARNLKubiquitination[1]
415FAISKLKKAGNQTGLubiquitination[1]
468EYNLSGTKRNFSNLKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1132 AA 
Protein Sequence
MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHSLGQA EGEYLKFPSG 60
EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH DILYRIRFYF 120
PHWYCSGSSR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180
MAVLDMMRIA KEKDQTPLAV YNSVSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 240
SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 300
GKHKESETLT EQDVQLYCDF PDIIDVSIKQ ANQECSNESR IVTVHKQDGK VLEIELSSLK 360
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 420
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSNLKDLLNC 480
YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGISDV QISPTLQRHN NVNQMVFHKI 540
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHKTEVLL KVLDKAHRNY SESFFEAASM 600
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 660
MHFLEEKSLI HGNVCAKNIL LIREEDRRTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 780
ANLINNCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 1020
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE 1080
LLKSNGRLPR PEGCPDEIYV IMTECWNNNV SQRPSFRDLS LRVDQIRDSI AA 1132 
Gene Ontology
 GO:0005901; C:caveola; IDA:MGI.
 GO:0005737; C:cytoplasm; TAS:MGI.
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0035401; F:histone kinase activity (H3-Y41 specific); IEA:Compara.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0004713; F:protein tyrosine kinase activity; IDA:MGI.
 GO:0000186; P:activation of MAPKK activity; IEA:Compara.
 GO:0031103; P:axon regeneration; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007167; P:enzyme linked receptor protein signaling pathway; IDA:MGI.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:MGI.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0060396; P:growth hormone receptor signaling pathway; IEA:Compara.
 GO:0009755; P:hormone-mediated signaling pathway; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Compara.
 GO:0035722; P:interleukin-12-mediated signaling pathway; IEA:Compara.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Compara.
 GO:0061180; P:mammary gland epithelium development; IMP:MGI.
 GO:0031959; P:mineralocorticoid receptor signaling pathway; IEA:Compara.
 GO:0030099; P:myeloid cell differentiation; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0022408; P:negative regulation of cell-cell adhesion; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IDA:MGI.
 GO:0045822; P:negative regulation of heart contraction; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:2001235; P:positive regulation of apoptotic signaling pathway; IMP:MGI.
 GO:0050867; P:positive regulation of cell activation; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:0043388; P:positive regulation of DNA binding; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IEA:Compara.
 GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0046677; P:response to antibiotic; ISO:MGI.
 GO:0033194; P:response to hydroperoxide; IEA:Compara.
 GO:0007262; P:STAT protein import into nucleus; IDA:MGI.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Compara.
 GO:0007260; P:tyrosine phosphorylation of STAT protein; IDA:MGI.
 GO:0042508; P:tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IEA:Compara.
 GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IEA:Compara. 
Interpro
 IPR019749; Band_41_domain.
 IPR019748; FERM_central.
 IPR000299; FERM_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
 IPR020693; Tyr_kinase_non-rcpt_Jak2. 
Pfam
 PF07714; Pkinase_Tyr
 PF00017; SH2 
SMART
 SM00295; B41
 SM00252; SH2
 SM00219; TyrKc 
PROSITE
 PS50057; FERM_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2 
PRINTS
 PR01823; JANUSKINASE.
 PR01825; JANUSKINASE2.
 PR00109; TYRKINASE.