CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012614
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 
Protein Synonyms/Alias
 CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1; U2(RNU2) small nuclear RNA auxiliary factor 1-like 1 
Gene Name
 ZRSR1 
Gene Synonyms/Alias
 U2AF1-RS1; U2AF1L1; U2AF1P; U2AF1RS1; U2AFBPL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
182ANCPFYSKTGACRFGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 203 309 RRM.
 ZN_FING 171 199 C3H1-type 1.
 ZN_FING 311 338 C3H1-type 2.
 MOD_RES 354 354 Phosphoserine (By similarity).
 MOD_RES 389 389 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MAALEKMTFP KKMTFPEKPS HKKYRAALKK EKRKKRRQEL ARLRDSGLSQ EEEEDTFIEE 60
QQLEEEKLLE RERERLHEEW LLREQKAQEE FRIKKEKEEA AKKWLEEQER KLKEQWKEQQ 120
RKEREEEEQK QQEKKEKEEA VQKMLDQAEN DLENSTTWQN PEPPVDFRVM EKDRANCPFY 180
SKTGACRFGD RCSRKHNFPT SSPTLLIKSM FTTFGMEQCR RDDYDPDASL EYSEEETYQQ 240
FLDFYEDVLP EFKNVGKVIQ FKVSCNLEPH LRGNVYVQYQ SEEECQAALS LFNGRWYAGR 300
QLQCEFCPVT RWKMAICGLF EIQQCPRGKH CNFLHVFRNP NNEFWEANRD IYLSSDQTGS 360
SFGKNSERRE KMGHHDHYYS RQRGRRNPSP DHTYKRNGES ERKKSSHRGK KSHKRTSKSR 420
ERHNSPSRGR NRHRSWDQGR RSQSRRSHRS RSQSSSRCRS RGRRKSGNRD RTVQSPQSK 479 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR009145; U2_small.
 IPR000571; Znf_CCCH. 
Pfam
 PF00642; zf-CCCH 
SMART
 SM00360; RRM
 SM00356; ZnF_C3H1 
PROSITE
 PS50102; RRM
 PS50103; ZF_C3H1 
PRINTS
 PR01848; U2AUXFACTOR.