| Tag | Content |
|---|
| CPLM ID | CPLM-023631 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein canopy homolog 2 |
Protein Synonyms/Alias | MIR-interacting saposin-like protein; Putative secreted protein Zsig9; Transmembrane protein 4 |
Gene Name | CNPY2 |
Gene Synonyms/Alias | MSAP; TMEM4; ZSIG9; UNQ1943/PRO4426 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | EIAQVDPKKTIQMGS | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
Sequence Annotation | DOMAIN 24 175 Saposin B-type.
MOTIF 179 182 Prevents secretion from ER (Potential).
DISULFID 28 171 By similarity.
DISULFID 31 164 By similarity.
DISULFID 86 137 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 182 AA |
Protein Sequence | MKGWGWLALL LGALLGTAWA RRSQDLHCGA CRALVDELEW EIAQVDPKKT IQMGSFRINP 60
DGSQSVVEVP YARSEAHLTE LLEEICDRMK EYGEQIDPST HRKNYVRVVG RNGESSELDL 120
QGIRIDSDIS GTLKFACESI VEEYEDELIE FFSREADNVK DKLCSKRTDL CDHALHISHD 180
EL 182 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0010629; P:negative regulation of gene expression; ISS:BHF-UCL. GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; ISS:BHF-UCL. GO:0010988; P:regulation of low-density lipoprotein particle clearance; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |