UniProt Accession

 TNNI3_MOUSE; P48787 

Genbank Protein ID

 Z22784; U09181; BC061171 

Genbank Nucleotide ID

 CAA80459.1; AAA19657.1; AAH61171.1 

Protein Name

 Troponin I, cardiac muscle 

Protein Synonyms/Alias

 Cardiac troponin I 

Gene Name

 Tnni3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	YATEPHAKKKSKISA	ubiquitination	[1]
51	ASRKLQLKTLMLQIA	ubiquitination	[1]
59	TLMLQIAKQEMEREA	ubiquitination	[1]
107	QLHARVDKVDEERYD	ubiquitination	[1]
118	ERYDVEAKVTKNITE	ubiquitination	[1]
121	DVEAKVTKNITEIAD	ubiquitination	[1]
132	EIADLTQKIYDLRGK	ubiquitination	[1]
165	ALLGTRAKESLDLRA	ubiquitination	[1]
175	LDLRAHLKQVKKEDI	ubiquitination	[1]
184	VKKEDIEKENREVGD	ubiquitination	[1]
194	REVGDWRKNIDALSG	acetylation	[2]
194	REVGDWRKNIDALSG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 REGION 33 80 Involved in binding TNC.
 REGION 130 151 Involved in binding TNC and actin.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 23 23 Phosphoserine; by PKA and PKD/PRKD1.
 MOD_RES 24 24 Phosphoserine; by PKA and PKD/PRKD1.
 MOD_RES 27 27 Phosphotyrosine (By similarity).
 MOD_RES 32 32 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 43 43 Phosphoserine; by PKC/PRKCE.
 MOD_RES 45 45 Phosphoserine; by PKC/PRKCE.
 MOD_RES 52 52 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 130 130 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 144 144 Phosphothreonine; by STK4/MST1 (By
 MOD_RES 151 151 Phosphoserine (By similarity).
 MOD_RES 167 167 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Actin-binding; Calcium; Complete proteome; Metal-binding; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0030017; C:sarcomere; IDA:MGI.
 GO:0005861; C:troponin complex; IEA:Compara.
 GO:0019855; F:calcium channel inhibitor activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:MGI.
 GO:0007507; P:heart development; IDA:MGI.
 GO:0032780; P:negative regulation of ATPase activity; IEA:Compara.
 GO:0006937; P:regulation of muscle contraction; IDA:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IEA:Compara.
 GO:0001980; P:regulation of systemic arterial blood pressure by ischemic conditions; IMP:MGI.
 GO:0006941; P:striated muscle contraction; IDA:MGI.
 GO:0001570; P:vasculogenesis; IDA:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 

Interpro

 IPR001978; Troponin.
 IPR021666; Troponin-I_N. 

Pfam

 PF00992; Troponin
 PF11636; Troponin-I_N 

SMART

  

PROSITE

  

PRINTS