CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027417
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 PF11_0331 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
240AFLDFPLKQYRLHLGacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MSLSIYGNRE SGQDVRTANV TAVQAISNIL KSSLGPQGLD KMLVDNIGDV TITNDGATIL 60
KQLEVQHPAA KILVNLSELQ DQEVGDGTTS VVLLASELLR RGNELIKMDI HPTTVICGYK 120
LAMKESVKYI KEKLSERVSN LGKDVIINIA KTTLSSKFIS YESDYFAKMV ANAIQSVKII 180
NESGKTKYPV SSVNVIKVHG MSSLDSKLIE GYAIMSGRAS QAMPTVIKNA KIAFLDFPLK 240
QYRLHLGVQV NINDPKELEK IRQKEKDITK ERVNKILESG ANVILTTQGI DDMPLKYFVE 300
AGAIAVRRVN KDDLRRIAKL TNGQIRLTLS SIDGTEKFEA SSLGYCDEVY EDKVGDWDLM 360
FFKGCRTSKS NTILLRGAND FVLDEMQRSI HDALCSVSRA LESNYVVVGG GCVEVALSVY 420
LEDFAKTLGS REQLAIAEFA ESLLVIPKIL ALNASYDSID LVCKLRAYHT KSQVMNIEDS 480
KDYKWYGLDL VNGKVANNLK NGVLEAMISK IKSIRFATEA TITILRIDDL IKLVPEERKM 540
EEEP 544 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; ISS:GeneDB_Pfalciparum.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; ISS:GeneDB_Pfalciparum.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012715; Chap_CCT_alpha.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.