CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022281
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 
Protein Synonyms/Alias
 Beta-ketoacyl-ACP synthase 
Gene Name
 OXSM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174FQTKGYNKVSPFFVPacetylation[1]
361LGDAAENKAIKHLFKacetylation[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. 
Sequence Annotation
 MOD_RES 174 174 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; Polymorphism; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 459 AA 
Protein Sequence
MSNCLQNFLK ITSTRLLCSR LCQQLRSKRK FFGTVPISRL HRRVVITGIG LVTPLGVGTH 60
LVWDRLIGGE SGIVSLVGEE YKSIPCSVAA YVPRGSDEGQ FNEQNFVSKS DIKSMSSPTI 120
MAIGAAELAM KDSGWHPQSE ADQVATGVAI GMGMIPLEVV SETALNFQTK GYNKVSPFFV 180
PKILVNMAAG QVSIRYKLKG PNHAVSTACT TGAHAVGDSF RFIAHGDADV MVAGGTDSCI 240
SPLSLAGFSR ARALSTNSDP KLACRPFHPK RDGFVMGEGA AVLVLEEYEH AVQRRARIYA 300
EVLGYGLSGD AGHITAPDPE GEGALRCMAA ALKDAGVQPE EISYINAHAT STPLGDAAEN 360
KAIKHLFKDH AYALAVSSTK GATGHLLGAA GAVEAAFTTL ACYYQKLPPT LNLDCSEPEF 420
DLNYVPLKAQ EWKTEKRFIG LTNSFGFGGT NATLCIAGL 459 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IDA:HGNC.
 GO:0006637; P:acyl-CoA metabolic process; IDA:HGNC.
 GO:0051792; P:medium-chain fatty acid biosynthetic process; IDA:HGNC.
 GO:0051790; P:short-chain fatty acid biosynthetic process; IDA:HGNC. 
Interpro
 IPR017568; 3-oxoacyl-ACP_synth-2.
 IPR018201; Ketoacyl_synth_AS.
 IPR014031; Ketoacyl_synth_C.
 IPR014030; Ketoacyl_synth_N.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 
Pfam
 PF00109; ketoacyl-synt
 PF02801; Ketoacyl-synt_C 
SMART
  
PROSITE
 PS00606; B_KETOACYL_SYNTHASE 
PRINTS