UniProt Accession

 NEDD8_DROME; Q9VJ33; Q29QE5 

Genbank Protein ID

 AE014134; BT024445 

Genbank Nucleotide ID

 AAF53724.1; ABC86507.1 

Protein Name

 NEDD8 

Protein Synonyms/Alias

 Neddylin; Ubiquitin-like protein Nedd8 

Gene Name

 Nedd8 

Gene Synonyms/Alias

 CG10679 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
48	QRLIFSGKQMNDDKT	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme Ubc12. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. 

Sequence Annotation

 REGION 70 72 Interaction with Uba3 (By similarity).
 CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Complete proteome; Developmental protein; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0031386; F:protein tag; NAS:UniProtKB.
 GO:0008283; P:cell proliferation; IMP:UniProtKB.
 GO:0048812; P:neuron projection morphogenesis; IMP:FlyBase.
 GO:0045116; P:protein neddylation; IMP:FlyBase.
 GO:0031647; P:regulation of protein stability; IMP:UniProtKB.
 GO:0030162; P:regulation of proteolysis; IMP:UniProtKB.
 GO:0008589; P:regulation of smoothened signaling pathway; IMP:UniProtKB.
 GO:0051438; P:regulation of ubiquitin-protein ligase activity; IMP:UniProtKB.
 GO:0030431; P:sleep; IMP:FlyBase. 

Interpro

 IPR000626; Ubiquitin.
 IPR019954; Ubiquitin_CS.
 IPR019956; Ubiquitin_subgr.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF00240; ubiquitin 

SMART

 SM00213; UBQ 

PROSITE

 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS

 PR00348; UBIQUITIN.