UniProt Accession

 DLG2_RAT; Q63622; P70548; Q62939 

Genbank Protein ID

 U49049; U50717; U53368 

Genbank Nucleotide ID

 AAB53243.1; AAC52643.1; AAB48562.1 

Protein Name

 Disks large homolog 2 

Protein Synonyms/Alias

 Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93 

Gene Name

 Dlg2 

Gene Synonyms/Alias

 Dlgh2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
165	VSEVSHSKAVEALKE	ubiquitination	[1]
171	SKAVEALKEAGSIVR	ubiquitination	[1]
201	IKLFKGPKGLGFSIA	ubiquitination	[1]
235	IDGGAAQKDGRLQVG	ubiquitination	[1]
511	DYARFEAKIHDLREQ	ubiquitination	[1]
618	KTVKFNAKPGVIDSK	ubiquitination	[1]
625	KPGVIDSKGDIPGLG	ubiquitination	[2]
639	GDDGYGTKTLRGQED	ubiquitination	[1, 2]
764	DVSGNAIKRLQVAQL	ubiquitination	[2]
791	EPLMEMNKRLTEEQA	ubiquitination	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). 

Sequence Annotation

 DOMAIN 98 184 PDZ 1.
 DOMAIN 193 279 PDZ 2.
 DOMAIN 421 501 PDZ 3.
 DOMAIN 536 606 SH3.
 DOMAIN 662 837 Guanylate kinase-like.
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 58 58 Phosphotyrosine (By similarity).
 MOD_RES 62 62 Phosphoserine (By similarity).
 MOD_RES 175 175 Phosphoserine (By similarity).
 MOD_RES 340 340 Phosphotyrosine (By similarity).
 MOD_RES 348 348 Phosphotyrosine (By similarity).
 MOD_RES 365 365 Phosphoserine (By similarity).
 MOD_RES 406 406 Phosphoserine (By similarity).
 MOD_RES 414 414 Phosphoserine (By similarity).
 MOD_RES 500 500 Phosphotyrosine (By similarity).
 MOD_RES 505 505 Phosphotyrosine (By similarity).
 MOD_RES 732 732 Phosphotyrosine (By similarity).
 MOD_RES 737 737 Phosphotyrosine (By similarity).
 LIPID 5 5 S-palmitoyl cysteine.
 LIPID 7 7 S-palmitoyl cysteine.  

Keyword

 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; SH3 domain; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 852 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0044224; C:juxtaparanode region of axon; IDA:MGI.
 GO:0016020; C:membrane; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; TAS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0008022; F:protein C-terminus binding; TAS:RGD.
 GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
 GO:0045161; P:neuronal ion channel clustering; IMP:RGD.
 GO:0043113; P:receptor clustering; IMP:RGD. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00625; Guanylate_kin
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF07653; SH3_2 

SMART

 SM00072; GuKc
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS50106; PDZ
 PS50002; SH3 

PRINTS