| Tag | Content |
|---|
| CPLM ID | CPLM-008254 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transketolase |
Protein Synonyms/Alias | TK |
Gene Name | Tkt |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 254 | GITGIEDKEAWHGKP | ubiquitination | [1] | | 283 | SQVQSKKKILATPPQ | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). |
Sequence Annotation | NP_BIND 123 125 Thiamine pyrophosphate (By similarity).
ACT_SITE 366 366 Proton donor (By similarity).
METAL 155 155 Magnesium (By similarity).
METAL 185 185 Magnesium (By similarity).
METAL 187 187 Magnesium; via carbonyl oxygen (By
BINDING 37 37 Substrate (By similarity).
BINDING 40 40 Thiamine pyrophosphate (By similarity).
BINDING 77 77 Thiamine pyrophosphate (By similarity).
BINDING 156 156 Thiamine pyrophosphate; via amide
BINDING 185 185 Thiamine pyrophosphate (By similarity).
BINDING 244 244 Thiamine pyrophosphate (By similarity).
BINDING 258 258 Substrate (By similarity).
BINDING 258 258 Thiamine pyrophosphate (By similarity).
BINDING 318 318 Substrate (By similarity).
BINDING 345 345 Substrate (By similarity).
BINDING 392 392 Thiamine pyrophosphate (By similarity).
BINDING 416 416 Substrate (By similarity).
BINDING 424 424 Substrate (By similarity).
BINDING 428 428 Thiamine pyrophosphate (By similarity).
BINDING 474 474 Substrate (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 6 6 N6-acetyllysine (By similarity).
MOD_RES 11 11 N6-acetyllysine (By similarity).
MOD_RES 144 144 N6-acetyllysine (By similarity).
MOD_RES 204 204 N6-acetyllysine (By similarity).
MOD_RES 241 241 N6-acetyllysine (By similarity).
MOD_RES 260 260 N6-acetyllysine (By similarity).
MOD_RES 275 275 Phosphotyrosine (By similarity).
MOD_RES 287 287 Phosphothreonine (By similarity).
MOD_RES 295 295 Phosphoserine (By similarity).
MOD_RES 603 603 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Calcium; Complete proteome; Direct protein sequencing; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Thiamine pyrophosphate; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 623 AA |
Protein Sequence | MEGYHKPDQQ KLQALKDTAN RLRISSIQAT TAAGSGHPTS CCSAAEIMAV LFFHTMRYKA 60
LDPRNPHNDR FVLSKGHAAP ILYAVWAEAG FLPEAELLNL RKISSDLDGH PVPKQAFTDV 120
ATGSLGQGLG AACGMAYTGK YFDKASYRVY CMLGDGEVSE GSVWEAMAFA GIYKLDNLVA 180
IFDINRLGQS DPAPLQHQVD VYQKRCEAFG WHAIIVDGHS VEELCKAFGQ AKHQPTAIIA 240
KTFKGRGITG IEDKEAWHGK PLPKNMAEQI IQEIYSQVQS KKKILATPPQ EDAPSVDIAN 300
IRMPTPPNYK VGDKIATRKA YGLALAKLGH ASDRIIALDG DTKNSTFSEL FKKEHPDRFI 360
ECYIAEQNMV SIAVGCATRD RTVPFCSTFA AFFTRAFDQI RMAAISESNI NLCGSHCGVS 420
IGEDGPSQMA LEDLAMFRSV PMSTVFYPSD GVATEKAVEL AANTKGICFI RTSRPENAII 480
YSNNEDFQVG QAKVVLKSKD DQVTVIGAGV TLHEALAAAE MLKKEKIGVR VLDPFTIKPL 540
DKKLILDCAR ATKGRILTVE DHYYEGGIGE AVSAVVVGEP GVTVTRLAVS QVPRSGKPAE 600
LLKMFGIDKD AIVQAVKGLV TKG 623 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD. GO:0005777; C:peroxisome; IDA:RGD. GO:0000287; F:magnesium ion binding; IDA:RGD. GO:0048029; F:monosaccharide binding; IDA:RGD. GO:0030976; F:thiamine pyrophosphate binding; IDA:RGD. GO:0004802; F:transketolase activity; IDA:RGD. GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IDA:RGD. GO:0046390; P:ribose phosphate biosynthetic process; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |