Tag | Content |
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CPLM ID | CPLM-013893 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleoside diphosphate kinase |
Protein Synonyms/Alias | NDK; NDP kinase; Nucleoside-2-P kinase |
Gene Name | ndk |
Gene Synonyms/Alias | TTHA0188 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
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55 | HYAEHREKPFFPGLV | acetylation | [1] |
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Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. |
Sequence Annotation | ACT_SITE 115 115 Pros-phosphohistidine intermediate (By BINDING 9 9 ATP. BINDING 57 57 ATP. BINDING 85 85 ATP. BINDING 91 91 ATP. BINDING 102 102 ATP. BINDING 112 112 ATP. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 137 AA |
Protein Sequence | MERTFVMIKP DGVRRGLVGE ILARFERKGF RIAALKLMQI SQELAERHYA EHREKPFFPG 60 LVRFITSGPV VAMVLEGPGV VAEVRKMMGA THPKDALPGT IRGDFATTID ENVIHGSATL 120 EDAQREIALF FRPEELL 137 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004550; F:nucleoside diphosphate kinase activity; IEA:HAMAP. GO:0006241; P:CTP biosynthetic process; IEA:HAMAP. GO:0006183; P:GTP biosynthetic process; IEA:HAMAP. GO:0006228; P:UTP biosynthetic process; IEA:HAMAP. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |