UniProt Accession

 RB11B_HUMAN; Q15907; B2R7I4; D6W671; Q2YDT2; Q8NI07 

Genbank Protein ID

 X79780; AF498947; AK312994; BT019536; CH471139; BC110081 

Genbank Nucleotide ID

 CAA56176.1; AAM21095.1; BAG35831.1; AAV38343.1; EAW68927.1; AAI10082.1 

Protein Name

 Ras-related protein Rab-11B 

Protein Synonyms/Alias

 GTP-binding protein YPT3 

Gene Name

 RAB11B 

Gene Synonyms/Alias

 YPT3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	IGDSGVGKSNLLSRF	ubiquitination	[1]
61	QVDGKTIKAQIWDTA	ubiquitination	[1, 2]
145	EARAFAEKNNLSFIE	ubiquitination	[2, 3]
179	IYRIVSQKQIADRAA	ubiquitination	[1, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity). 

Sequence Annotation

 NP_BIND 18 26 GTP.
 NP_BIND 66 70 GTP.
 NP_BIND 124 127 GTP.
 NP_BIND 154 156 GTP.
 MOTIF 40 48 Effector region (By similarity).
 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 215 215 Cysteine methyl ester (Potential).
 LIPID 214 214 S-geranylgeranyl cysteine (By
 LIPID 215 215 S-geranylgeranyl cysteine (By  

Keyword

 3D-structure; Acetylation; Cell cycle; Cell membrane; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; IDA:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0032402; P:melanosome transport; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.