CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006312
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator MlrA 
Protein Synonyms/Alias
 MerR-like regulator A 
Gene Name
 mlrA 
Gene Synonyms/Alias
 yehV; b2127; JW2115 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
31QRRYGLLKPQRTDGGacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Transcriptional activator of the csg genes required for production of the curli (AgF). 
Sequence Annotation
 DOMAIN 3 72 HTH merR-type.
 DNA_BIND 6 25 H-T-H motif (Potential).  
Keyword
 Activator; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 243 AA 
Protein Sequence
MALYTIGEVA LLCDINPVTL RAWQRRYGLL KPQRTDGGHR LFNDADIDRI REIKRWIDNG 60
VQVSKVKMLL SNENVDVQNG WRDQQETLLT YLQSGNLHSL RTWIKERGQD YPAQTLTTHL 120
FIPLRRRLQC QQPTLQALLA ILDGVLINYI AICLASARKK QGKDALVVGW NIQDTTRLWL 180
EGWIASQQGW RIDVLAHSLN QLRPELFEGR TLLVWCGENR TSAQQQQLTS WQEQGHDIFP 240
LGI 243 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009061; DNA-bd_dom_put.
 IPR000551; Tscrpt_reg_HTH_MerR. 
Pfam
  
SMART
 SM00422; HTH_MERR 
PROSITE
 PS00552; HTH_MERR_1
 PS50937; HTH_MERR_2 
PRINTS