UniProt Accession

 COMD7_HUMAN; Q86VX2; A2BHJ2; B3KTZ2; Q5JYB0; Q96SI7; Q9BW53 

Genbank Protein ID

 AY542162; AK027893; AK096307; AL035071; BX640505; FO393400; CH471077; BC000628; BC047440; BI821799 

Genbank Nucleotide ID

 AAS22244.1; BAB55436.1; BAG53254.1; EAW76360.1; AAH00628.3; AAH47440.1 

Protein Name

 COMM domain-containing protein 7 

Protein Synonyms/Alias

  

Gene Name

 COMMD7 

Gene Synonyms/Alias

 C20orf92 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
73	GSLRSIVKSLLLVPN	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Associates with the NF-kappa-B complex and suppresses its transcriptional activity. 

Sequence Annotation

 DOMAIN 133 200 COMM.  

Keyword

 Alternative splicing; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0051059; F:NF-kappaB binding; IDA:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB. 

Interpro

 IPR017920; COMM.
 IPR009886; HCaRG. 

Pfam

 PF07258; HCaRG 

SMART

  

PROSITE

 PS51269; COMM 

PRINTS