UniProt Accession

 OXA1L_HUMAN; Q15070; B4DPA2 

Genbank Protein ID

 X80695; AJ001981; BX248001; BX248295; AK298249; BC001669 

Genbank Nucleotide ID

 CAA56712.1; CAA05127.1; CAD62333.1; CAD62623.1; BAG60514.1; AAH01669.2 

Protein Name

 Mitochondrial inner membrane protein OXA1L 

Protein Synonyms/Alias

 Hsa; OXA1Hs; Oxidase assembly 1-like protein; OXA1-like protein 

Gene Name

 OXA1L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
178	NHLPEIQKFSSRIRE	ubiquitination	[1]
187	SSRIREAKLAGDHIE	ubiquitination	[2]
197	GDHIEYYKASSEMAL	ubiquitination	[3]
207	SEMALYQKKHGIKLY	ubiquitination	[3]
343	PAVRTVLKIPQRVVH	ubiquitination	[2]
370	ESFKKGWKNAEMTRQ	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 435 AA 

Protein Sequence

Gene Ontology

 GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB.
 GO:0005746; C:mitochondrial respiratory chain; NAS:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0097177; F:mitochondrial ribosome binding; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0009060; P:aerobic respiration; IMP:UniProtKB.
 GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IMP:UniProtKB.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
 GO:0032780; P:negative regulation of ATPase activity; IMP:UniProtKB.
 GO:0051354; P:negative regulation of oxidoreductase activity; IMP:UniProtKB.
 GO:0051205; P:protein insertion into membrane; IEA:InterPro.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB. 

Interpro

 IPR001708; Membrane_insert_OXA1/ALB3/YidC. 

Pfam

 PF02096; 60KD_IMP 

SMART

  

PROSITE

  

PRINTS