| Tag | Content |
|---|
| CPLM ID | CPLM-022784 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Periplakin |
Protein Synonyms/Alias | |
Gene Name | Ppl |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 36 | DLIEQLQKNADQVER | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. |
Sequence Annotation | REPEAT 214 315 Spectrin 1.
REPEAT 321 483 Spectrin 2.
REPEAT 503 610 Spectrin 3.
REPEAT 1650 1684 Plectin 1.
REPEAT 1699 1734 Plectin 2.
MOD_RES 14 14 Phosphoserine.
MOD_RES 885 885 Phosphoserine (By similarity).
MOD_RES 1656 1656 Phosphoserine. |
Keyword | Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Keratinization; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1755 AA |
Protein Sequence | MHSLFRKRNK GKYSPTVQTR SISNKELSDL IEQLQKNADQ VERNIVDTEA KMQSDLARMQ 60
EGQLPEHRDA ALQNVSDSEK LLYVLEADSA IAKHMKHPQG DMIAEDIRQL KERVTNLRGK 120
HKQMYSLAVK EADPRVNWDT LVDEKLDKLS SQSFGTDLPL VDSQVEQHNI FHNEVKAIGP 180
HLAKDKEQNS ELQAKYQKLL TASQARQQHL SSLQDYMQRC TNELYWLDQQ AKGRMQYDWS 240
DRNLDYPSRR RQYENFINRN LEAKEERINK LHTEGDQLLT AEHPGRNSIE AHMEAVHAEW 300
KEYLNLLICE ESHLKYMEDY HQFHKDMKDA QELLRKVDSD LNQKYSPDFK DRYQIELLLR 360
ELDDQEKALD KYEDVVRGLQ RRGQQVVPLK YRRETPLKPI PVEALCDFES DQGLISRGYS 420
YTLQKNNGES WELTDSTGKK LAAPAVCFII PPTDPEALAL ADSLGSQYRS VRQKATGSKH 480
ALQQRHEVLR TENPGDASDL QGRQLLAGLD KVASDLDRQE KAITGILRPP LEQGRAIEDS 540
AERAKGLKNI TNELLQIEPE KTQCTAECEA FVQALPASGT APLLKTRVED TNQKYERLVW 600
LLEAAQEKVD VANRLENSLQ RGRELLASYE NRLIQDDTMP ESGHVLDRKR QELEAMASEL 660
QAHKSLLGEV GKNLQVAKQC SSSLASRFQE HCPDLERQEA EVHKLNQRFN NLSQQVERRA 720
QSLQSARAAY DEYCSGYNRV LQFLAKTPSY EPQETDSLGQ METKLKNQKN LLDELASREQ 780
EVQKVYADSQ QYQQAVKDYE LEAEKLRSLL DLENGRNSHV NKRARLQSPA AKVKEEEAAL 840
AAKFTEVNAI NRQRLQNLEF ALNLLRQQPE AGVTHETLQG GKLSSGMEET WKIKKELEEE 900
IERRQQLENE VKSAQEEIQT LKDQGPQESL VRKEVLKKVP DPALEESFQQ LQQTLAEEQH 960
KNQLLQEELG ALQLRLQALE QETRDGGQEY VVKEVLRIEP DRAQEDEVLQ LREELEALRR 1020
QKGAREAEVL LLQQRVAALA AEKSRVQEKV TEREVVKLQN DPQLEAEYRR LQEEHQREGT 1080
LREKQEEELS FLQAKLRRLE KERAMAEGKI TVKEVLKVEK DAAVEREVND LTRQYEDEAA 1140
KARSGQREKT ELLRKIWALE EENAKVVVQE KVREIVRPDP KAESEVANLR LELVEQERKF 1200
RGAEEQLKSY QSELEALRNR GPQVEVKEVT KEVIKYTTDP ETEQELQRLR EEIMDKTRLI 1260
ERCDLEIYQL KQEIQALKDT KPQVQTREVV QEILQFQEDP QTKKEVESLR IQLSEEQKKQ 1320
VDLEGERASQ EEKIKRKEEE LAQQRKERVV RQEVVQYEDE PDLRAEVTAF TNSIDAELRQ 1380
IDKLHVELRR LQHRRAELER QLEELERERQ ARRAAELEVQ RLQQRLAALE QEEAKTGEKV 1440
THTQKVVLQQ DPQQTREHAL LRAQLEEERH RRQLLEGELE PLRRKLAALE KAEIKEKVVF 1500
SESVQVEKGD TEQEIQRLKK SLEEESQSKR ELDSEVTRLE AKLSELEFYN SKSSKELDFL 1560
REENHKLQLE RQNLQLETRR LQSEIEMAAT ETRDLKNITT IDSGTHLNSR LWSLEKELDD 1620
LKKMSKDKDL EIDELQRRLG SVAVKREQRE NHLRRSIVVI DPDTGRELSP EEAHRAGLID 1680
WKMFVKLRSQ ECDWEEISVK GPNGESSVIH DRKSGKKFSI EDALQSGRLT AAQYDRYVNK 1740
DMSIQELAVL VSGQK 1755 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |