| Tag | Content |
|---|
| CPLM ID | CPLM-024120 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | STE20/SPS1-related proline-alanine-rich protein kinase |
Protein Synonyms/Alias | Ste-20-related kinase; Serine/threonine-protein kinase 39 |
Gene Name | Stk39 |
Gene Synonyms/Alias | Spak |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 361 | NREYLIEKLLTRTPD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a mediator of stress-activated signals. |
Sequence Annotation | DOMAIN 75 349 Protein kinase.
NP_BIND 81 89 ATP (By similarity).
MOTIF 372 378 Nuclear localization signal (Potential).
MOTIF 399 403 Caspase cleavage related site.
ACT_SITE 204 204 Proton acceptor (By similarity).
BINDING 104 104 ATP (By similarity).
MOD_RES 321 321 Phosphoserine; by PKC/PRKCQ (By
MOD_RES 361 361 N6-acetyllysine (By similarity).
MOD_RES 366 366 Phosphothreonine.
MOD_RES 382 382 Phosphoserine (By similarity).
MOD_RES 383 383 Phosphoserine.
MOD_RES 397 397 Phosphoserine. |
Keyword | Acetylation; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 556 AA |
Protein Sequence | MAEPSGSPVH VQLSQQAAPV TAAAATAPAA ATSAPAPAPA PAPAASAAPA PAPAAAPAPA 60
PAAQAVGWPI CRDAYELQEV IGSGATAVVQ AALCKPRQER VAIKRINLEK CQTSMDELLK 120
EIQAMSQCSH PNVVTYYTSF VVKDELWLVM KLLSGGSMLD IIKYIVNRGE HKNGVLEEAI 180
IATILKEVLE GLDYLHRNGQ IHRDLKAGNI LLGEDGSVQI ADFGVSAFLA TGGDVTRNKV 240
RKTFVGTPCW MAPEVMEQVR GYDFKADMWS FGITAIELAT GAAPYHKYPP MKVLMLTLQN 300
DPPTLETGVE DKEMMKKYGK SFRKLLSLCL QKDPSKRPTA AELLKCKFFQ KAKNREYLIE 360
KLLTRTPDIA QRAKKVRRVP GSSGHLHKTE DGDWEWSDDE MDEKSEEGKA AASQEKSRRV 420
KEENSEISVN AGGIPEQIQS LSVHDSQAQP NANEDYREGP CAVNLVLRLR NSRKELNDIR 480
FEFTPGRDTA DGVSQELFSA GLVDGHDVVI VAANLQKIVD DPKALKTLTF KLASGCDGSE 540
IPDEVKLIGF AQLSVS 556 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IDA:MGI. GO:0016323; C:basolateral plasma membrane; IDA:MGI. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara. GO:0050727; P:regulation of inflammatory response; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |