CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005374
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable DNA-binding protein SNT1 
Protein Synonyms/Alias
 SANT domain-containing protein 1 
Gene Name
 SNT1 
Gene Synonyms/Alias
 YCR033W; YCR33W; YCR592 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
33HPSAVYSKNSFPKSSacetylation[1]
198YSPDVTNKLETNNVSacetylation[1]
257HQREPFWKANSTTILacetylation[1]
285KKFHDANKLDKPEASacetylation[1]
517ATGLILTKIISKIKKacetylation[1]
534HLKKINLKHDYFDLQacetylation[1]
576EHELMEQKRREEGIEacetylation[1]
739RKMSAAAKRRKRKERubiquitination[2]
758EVEVDESKEESTNTIacetylation[1]
770NTIEKEEKSENNAEEacetylation[1]
888HKSAPEHKTSYWSVRacetylation[1]
949LVDETDLKRDGTSSEacetylation[1]
1022FHRDTFSKISAPLTTacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. 
Sequence Annotation
 DOMAIN 668 720 SANT.
 DOMAIN 884 938 HTH myb-type.
 DNA_BIND 911 934 H-T-H motif (By similarity).
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 796 796 Phosphothreonine.
 MOD_RES 1037 1037 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1226 AA 
Protein Sequence
MGYPPPTRRL GDKKRYHYSN NPNRRHPSAV YSKNSFPKSS NNGFVSSPTA DNSTNPSVTP 60
STASVPLPTA APGSTFGIEA PRPSRYDPSS VSRPSSSSYS STRKIGSRYN PDVERSSSTT 120
SSTPESMNTS TITHTNTDIG NSRYSRKTMS RYNPQSTSST NVTHFPSALS NAPPFYVANG 180
SSRRPRSMDD YSPDVTNKLE TNNVSSVNNN SPHSYYSRSN KWRSIGTPSR PPFDNHVGNM 240
TTTSNTNSIH QREPFWKANS TTILKSTHSQ SSPSLHTKKF HDANKLDKPE ASVKVETPSK 300
DETKAISYHD NNFPPRKSVS KPNAPLEPDN IKVGEEDALG KKEVHKSGRE IAKEHPTPVK 360
MKEHDELEAR AKKVSKINID GKQDEIWTTA KTVASAVEVS KESQKELTRS VERKESPEIR 420
DYERAYDPKA LKTDVTKLTV DNDNKSYEEP LEKVEGCIFP LPKAETRLWE LKNQKRNKII 480
SEQKYLLKKA IRNFSEYPFY AQNKLIHQQA TGLILTKIIS KIKKEEHLKK INLKHDYFDL 540
QKKYEKECEI LTKLSENLRK EEIENKRKEH ELMEQKRREE GIETEKEKSL RHPSSSSSSR 600
RRNRADFVDD AEMENVLLQI DPNYKHYQAA ATIPPLILDP IRKHSYKFCD VNNLVTDKKL 660
WASRILKDAS DNFTDHEHSL FLEGYLIHPK KFGKISHYMG GLRSPEECVL HYYRTKKTVN 720
YKQLLIDKNK KRKMSAAAKR RKRKERSNDE EVEVDESKEE STNTIEKEEK SENNAEENVQ 780
PVLVQGSEVK GDPLGTPEKV ENMIEQRGEE FAGELENAER VNDLKRAHDE VGEESNKSSV 840
IETNNGVQIM DPKGAVQNGY YPEETKELDF SLENALQRKK HKSAPEHKTS YWSVRESQLF 900
PELLKEFGSQ WSLISEKLGT KSTTMVRNYY QRNAARNGWK LLVDETDLKR DGTSSESVQQ 960
SQILIQPERP NINAYSNIPP QQRPALGYFV GQPTHGHNTS ISSIDGSIRP FGPDFHRDTF 1020
SKISAPLTTL PPPRLPSIQF PRSEMAEPTV TDLRNRPLDH IDTLADAASS VTNNQNFSNE 1080
RNAIDIGRKS TTISNLLNNS DRSMKSSFQS ASRHEAQLED TPSMNNIVVQ EIKPNITTPR 1140
SSSISALLNP VNGNGQSNPD GRPLLPFQHA ISQGTPTFPL PAPRTSPISR APPKFNFSND 1200
PLAALAAVAS APDAMSSFLS KKENNN 1226 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0034967; C:Set3 complex; IDA:SGD.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0016575; P:histone deacetylation; IDA:UniProtKB.
 GO:0045835; P:negative regulation of meiosis; IDA:UniProtKB.
 GO:0032874; P:positive regulation of stress-activated MAPK cascade; IMP:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:SGD. 
Interpro
 IPR007137; DUF348.
 IPR009057; Homeodomain-like.
 IPR017930; Myb_dom.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 
Pfam
 PF03990; DUF348
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51294; HTH_MYB
 PS51293; SANT 
PRINTS