CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024520
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 726 
Protein Synonyms/Alias
  
Gene Name
 ZNF726 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
97GVEDSFQKVILRRFEubiquitination[1, 2, 3]
255KVTHTGEKPYKCEECubiquitination[2]
314HIGEKPYKCEECGKAubiquitination[2]
594HTGEKPYKCDECGKSubiquitination[2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 4 75 KRAB.
 ZN_FING 173 195 C2H2-type 1; degenerate.
 ZN_FING 201 223 C2H2-type 2.
 ZN_FING 229 251 C2H2-type 3; degenerate.
 ZN_FING 257 279 C2H2-type 4.
 ZN_FING 285 307 C2H2-type 5.
 ZN_FING 313 335 C2H2-type 6.
 ZN_FING 341 363 C2H2-type 7.
 ZN_FING 369 391 C2H2-type 8.
 ZN_FING 397 419 C2H2-type 9.
 ZN_FING 425 447 C2H2-type 10.
 ZN_FING 453 475 C2H2-type 11.
 ZN_FING 481 503 C2H2-type 12.
 ZN_FING 509 531 C2H2-type 13.
 ZN_FING 537 559 C2H2-type 14.
 ZN_FING 565 587 C2H2-type 15.
 ZN_FING 593 615 C2H2-type 16.
 ZN_FING 621 645 C2H2-type 17; degenerate.
 ZN_FING 651 673 C2H2-type 18.
 ZN_FING 679 701 C2H2-type 19.
 ZN_FING 707 729 C2H2-type 20; degenerate.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 738 AA 
Protein Sequence
MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP DLIICLEKEK 60
EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL RRFEKCGHEN LQLRKGCKSV 120
DECKVHKEGY NGLNQCFTTT QGKASQCGKY LKVFYKFINL NRYKIRHTRK KPFKCKNCVK 180
SFCMFSHKTQ HKSIYTTEKS YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ 240
SSNYTTHKVT HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL 300
TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF SQFGHLTTHR 360
IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE ECGKAFHRSS NLTKHKIIHT 420
GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE KPYKCEECSK AFSRSSALTT HKRMHTGEKP 480
YKCEECGKAF SQSSTLTAHK IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE 540
ECGKTFNQSS NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK 600
SFIWSSTLFK HKIIHTGEKP YKCEECGKAF NHSQILLHIR HKRMHTGEKP YKCEECGKSF 660
NLSSTFIKHK VIHTGVKLYK CEECGKVFFW SSALTRHKKI HAGQQPYKWE KIGKAFNQSS 720
HLTTDKITHI GEKSYKCE 738 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS