Tag | Content |
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CPLM ID | CPLM-016508 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase SMG1 |
Protein Synonyms/Alias | SMG-1 |
Gene Name | Smg1 |
Gene Synonyms/Alias | Kiaa0421 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1285 | PDPRELQKSIEVQLL | ubiquitination | [1] | 1630 | WAYRWGRKVVDNASQ | ubiquitination | [1] | 3431 | HLLKAMAKDEEAALA | ubiquitination | [1] | 3557 | DVMSQNAKKLIQKNL | ubiquitination | [2] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity). |
Sequence Annotation | DOMAIN 1129 1864 FAT. REPEAT 1815 1850 HEAT. DOMAIN 2148 2476 PI3K/PI4K. DOMAIN 3626 3658 FATC. MOD_RES 171 171 N6-acetyllysine (By similarity). MOD_RES 3547 3547 Phosphothreonine (By similarity). MOD_RES 3553 3553 Phosphoserine (By similarity). MOD_RES 3567 3567 Phosphoserine (By similarity). MOD_RES 3570 3570 Phosphothreonine (By similarity). MOD_RES 3574 3574 Phosphothreonine. |
Keyword | Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA repair; Kinase; Manganese; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3658 AA |
Protein Sequence | MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 60 SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 120 HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 180 LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 240 SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 300 VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 360 QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 420 PITEAYVTDV LYRVMRCVTA ANQVFFSEAV LTAANECVGV LLGSLDPSMT IHCDMVITYG 480 LDQLENCQTC GTDYIISVLN LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV 540 AVAHAVYQAV LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 600 NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD LAVHFPAIQY 660 AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA TKKHFSIILN LLGILLKKDN 720 LNQDTRKLLM TWALEVAVLM KKSETYAPLF SLPSFHKFSK GLLANTLVED VNICLQACSS 780 LHALSSSLPD DLLQRCVDVC RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS 840 LALRSHMSKA PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 900 RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA HTLNPDQDVS 960 QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVI RTFFYTNRQT 1020 CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNS LTQGSELEVT IMMVVEALCE 1080 LHCPEAIQGI AVWSSSAVGK NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF 1140 DKSVLTLANA GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 1200 VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL PGENINLLAG 1260 GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT ALNHMEQDQK WQSLTENVVK 1320 YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL QLYCSSALEN TVSNRLSTED CLIPLFSDAL 1380 RSCKQHDVRP WMQALRYTMY QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT 1440 RLLAQCSEVQ LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 1500 MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ QNLSGLSTLS 1560 RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG QLYHLSSVQA PEVAKSWAAL 1620 ASWAYRWGRK VVDNASQGEG VRLLPREKSE VQNLLPDTIT EEEKERIYGI LGQAVCRPAG 1680 IQDEDITLQI TESEDNEDDD MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS 1740 LYKLSCSAYF TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 1800 LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS PHLILYPAIV 1860 GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG SPPASQDSNK DEPKSGLNED 1920 QAMMQDCYSK IVDKLSSANP TMVLQVQMLV AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ 1980 QLEDEVKRVQ NNNTLRKEEK IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD 2040 NYGDAIDNAL EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 2100 TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL 2160 DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ 2220 QREAALQAQK AQDSYQTPQN PSIVPRPSEL YYSKIGPALK TVGLSLDVSR RDWPLHVMKA 2280 VLEELMEATP PNLLAKELWS SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL 2340 IDMTTGEVVH IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 2400 MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR EMEREITRSL 2460 FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL TDVEKLQGKL LEEIEFLEGA 2520 EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA IQVKLNEFEQ WITHYQAAFN NLEATQLASL 2580 LQEISTQMDL GPPSYVPATA FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH 2640 HYATVALQYP KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 2700 ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF LHENGEEGSL 2760 SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA WFLEELCSMS GNVTCLVQLL 2820 KQCHLVPQDL DIPNPVEASE AVHLANGVYT SLQELNSNFR QIIFPEALRC LMKGECTLES 2880 MLHELDSLIE QTTDGVPLQT LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ 2940 PRNGSVDETP KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 3000 TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ NTVNGPVQIV 3060 NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL GLTLCSFISA LGVDIIAQVE 3120 AKDFGAESKV SVDDLCKKAV EHNIQVGKFS QLVMNRATVL ASSYDTAWKK HDLVRRLETS 3180 ISSCKTSLQR VQLHIAMFQW QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI 3240 GTVQEKLAAL EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 3300 SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR LLQRVDTTLE 3360 HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET IQSLVDSVKT VLTGHNRQLG 3420 DVKHLLKAMA KDEEAALADA EDIPYESSVR QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ 3480 EHVEMLQEIT PTLKELKTQS QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR 3540 SNTGQKTQPD VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 3600 ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL YEGWTAWV 3658 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara. GO:0046854; P:phosphatidylinositol phosphorylation; IEA:Compara. GO:0046777; P:protein autophosphorylation; IEA:Compara. |
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