CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase SMG1 
Protein Synonyms/Alias
 SMG-1 
Gene Name
 Smg1 
Gene Synonyms/Alias
 Kiaa0421 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1285PDPRELQKSIEVQLLubiquitination[1]
1630WAYRWGRKVVDNASQubiquitination[1]
3431HLLKAMAKDEEAALAubiquitination[1]
3557DVMSQNAKKLIQKNLubiquitination[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ (By similarity). 
Sequence Annotation
 DOMAIN 1129 1864 FAT.
 REPEAT 1815 1850 HEAT.
 DOMAIN 2148 2476 PI3K/PI4K.
 DOMAIN 3626 3658 FATC.
 MOD_RES 171 171 N6-acetyllysine (By similarity).
 MOD_RES 3547 3547 Phosphothreonine (By similarity).
 MOD_RES 3553 3553 Phosphoserine (By similarity).
 MOD_RES 3567 3567 Phosphoserine (By similarity).
 MOD_RES 3570 3570 Phosphothreonine (By similarity).
 MOD_RES 3574 3574 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA repair; Kinase; Manganese; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3658 AA 
Protein Sequence
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 60
SAVVSRQRHD DTRGHADIQN DEKGGYSVNG GSGENTYGRK SLGQELRINN VTSPEFTSVQ 120
HGSRALATKD MRKSQERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 180
LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 240
SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 300
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 360
QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 420
PITEAYVTDV LYRVMRCVTA ANQVFFSEAV LTAANECVGV LLGSLDPSMT IHCDMVITYG 480
LDQLENCQTC GTDYIISVLN LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV 540
AVAHAVYQAV LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 600
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD LAVHFPAIQY 660
AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA TKKHFSIILN LLGILLKKDN 720
LNQDTRKLLM TWALEVAVLM KKSETYAPLF SLPSFHKFSK GLLANTLVED VNICLQACSS 780
LHALSSSLPD DLLQRCVDVC RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS 840
LALRSHMSKA PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 900
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA HTLNPDQDVS 960
QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVI RTFFYTNRQT 1020
CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNS LTQGSELEVT IMMVVEALCE 1080
LHCPEAIQGI AVWSSSAVGK NLLWINSVAQ QAEGRFEKAS VEYQEHLCAM TGVDCCISSF 1140
DKSVLTLANA GRNSASPKHS LNGESRKTVL SKSIDSSPEV ISYLGNKACE CYISIADWAA 1200
VQEWQNAVHD LKKNSSSTSL NLKADFNYIK SLSSFESGEF VECTEQLELL PGENINLLAG 1260
GSKEKIDMKK LLPNMLSPDP RELQKSIEVQ LLRSSVFLAT ALNHMEQDQK WQSLTENVVK 1320
YLKQTSRIAI GPLRLSTLTV SQSLPVLSTL QLYCSSALEN TVSNRLSTED CLIPLFSDAL 1380
RSCKQHDVRP WMQALRYTMY QNQLLEKIKE QTVPIRSHLM ELGLTAAKFA RKRGNVSLAT 1440
RLLAQCSEVQ LGKTTTAQDL VQHFKKLSTQ GQVDEKWGPE LDIEKTKLLY TAGQSTHAME 1500
MLSSCAISFC KSAKAEYAVA KSILTLAKWV QAEWKEISGQ LRQVYRAQQQ QNLSGLSTLS 1560
RNILALIELP SANTVGEEHP RIESESTVHI GVGEPDFILG QLYHLSSVQA PEVAKSWAAL 1620
ASWAYRWGRK VVDNASQGEG VRLLPREKSE VQNLLPDTIT EEEKERIYGI LGQAVCRPAG 1680
IQDEDITLQI TESEDNEDDD MVDVIWRQLI SSCPWLSELD ENATEGVIKV WRKVVDRIFS 1740
LYKLSCSAYF TFLKLNAGQV LLDEDDPRLH LSHRAEQSTD DVIVMATLRL LRLLVKHAGE 1800
LRQYLEHGLE TTPTAPWRGI IPQLFSRLNH PEVYVRQSIC NLLCRVAQDS PHLILYPAIV 1860
GTISLSSESQ ASGNKYSSAI PTLLGNIQGE ELLVSECEGG SPPASQDSNK DEPKSGLNED 1920
QAMMQDCYSK IVDKLSSANP TMVLQVQMLV AELRRVTVLW DELWLGVLLQ QHMYVLRRIQ 1980
QLEDEVKRVQ NNNTLRKEEK IAIMREKHTA LMKPIVFALE HVRSITAAPA ETPHEKWFQD 2040
NYGDAIDNAL EKLKTPSNPA KPGSSWIPFK EIMLSLQQRA QKRASYILRL DEISPWLAAM 2100
TNTEIALPGE VSARDTVTIH SVGGTITILP TKTKPKKLLF LGSDGKSYPY LFKGLEDLHL 2160
DERIMQFLSI VNTMFATINR QETPRFHARH YSVTPLGTRS GLIQWVDGAT PLFGLYKRWQ 2220
QREAALQAQK AQDSYQTPQN PSIVPRPSEL YYSKIGPALK TVGLSLDVSR RDWPLHVMKA 2280
VLEELMEATP PNLLAKELWS SCTTPDEWWR VTQSYARSTA VMSMVGYIIG LGDRHLDNVL 2340
IDMTTGEVVH IDYNVCFEKG KSLRVPEKVP FRMTQNIETA LGVTGVEGVF RLSCEQVLHI 2400
MRRGRETLLT LLEAFVYDPL VDWTAGGEAG FAGAVYGGGG QQAESKQSKR EMEREITRSL 2460
FSSRVAEIKV NWFKNRDEML VVLPKLDSSL DEYLSLQEQL TDVEKLQGKL LEEIEFLEGA 2520
EGVDHPSHTL QHRYSEHTQL QTQQRAVQEA IQVKLNEFEQ WITHYQAAFN NLEATQLASL 2580
LQEISTQMDL GPPSYVPATA FLQNAGQAHL ISQCEQLEGE VGALLQQRRS VLRGCLEQLH 2640
HYATVALQYP KAIFQKHRIE QWKAWMEELI CNTTVERCQE LYRKYEMQYA PQPPPTVCQF 2700
ITATEMTLQR YAADINSRLI RQVERLKQEA VTVPVCEDQL KEIERCIKVF LHENGEEGSL 2760
SLASVIISAL CTLTRRNLMM EGAASSAGEQ LVDLTSRDGA WFLEELCSMS GNVTCLVQLL 2820
KQCHLVPQDL DIPNPVEASE AVHLANGVYT SLQELNSNFR QIIFPEALRC LMKGECTLES 2880
MLHELDSLIE QTTDGVPLQT LVESLQAYLR NTAMGLEEET HAHYIDVARM LHAQYGELIQ 2940
PRNGSVDETP KMSAGQMLLV AFDGMFAQVE TAFGLLVEKL NKMEIPVAWR KIDIIREARS 3000
TQVNFFDDDN HRQVLEEIFF LKRLQTIKEF FRLCGTFSKT LSGSSSLEDQ NTVNGPVQIV 3060
NVKTLFRNSC FSEDQMAKPI KAFTADFVRQ LLIGLPNQAL GLTLCSFISA LGVDIIAQVE 3120
AKDFGAESKV SVDDLCKKAV EHNIQVGKFS QLVMNRATVL ASSYDTAWKK HDLVRRLETS 3180
ISSCKTSLQR VQLHIAMFQW QHEDLLISRP QAMSVTPPRS AILTSMKKKL HALSQIETSI 3240
GTVQEKLAAL EASIEQRLKW AGGANPALAP VLQDFEATIA ERRNLVLKES QRANQVTFLC 3300
SNIIHFESLR TRTAEALSLD AALFELIKRC QQMCSFASQF NSSVSELELR LLQRVDTTLE 3360
HPIGSSEWLL SAHKQLTQDM STQRAVQTEK EQQIETVCET IQSLVDSVKT VLTGHNRQLG 3420
DVKHLLKAMA KDEEAALADA EDIPYESSVR QFLAEYKSWQ DNIQTVLFTL VQAMGQVRSQ 3480
EHVEMLQEIT PTLKELKTQS QSIYNNLVSF ASPLVTDAAN ECSSPTSSAT YQPSFAAAVR 3540
SNTGQKTQPD VMSQNAKKLI QKNLATSADT PPSTIPGTGK SIACSPKKAV RDPKTGKAVQ 3600
ERNSYAVSVW KRVKAKLEGR DVDPNRRMSV AEQVDYVIKE ATNLDNLAQL YEGWTAWV 3658 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
 GO:0018105; P:peptidyl-serine phosphorylation; IEA:Compara.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR014009; PIK_FAT. 
Pfam
 PF02260; FATC
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS50077; HEAT_REPEAT
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS