CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043217
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 T-complex protein 1 subunit theta 
Protein Synonyms/Alias
  
Gene Name
 Cct8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
147VDNIRVCKILGSGIYacetylation[1]
165VLHGMVFKKETEGDVacetylation[1]
176EGDVTSVKDAKIAVYubiquitination[2]
195DGMITETKGTVLIKTubiquitination[2]
362ATEIELAKQITSYGEubiquitination[2]
469VDQIIMAKPAGGPKPubiquitination[2]
475AKPAGGPKPPSGKKDubiquitination[2]
480GPKPPSGKKDWDDDQubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MALHVPKAPG FAQMLKDGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINRL 60
EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR 120
IGLSVSEAIS IFPDSGNFNV DNIRVCKILG SGIYSSSVLH GMVFKKETEG DVTSVKDAKI 180
AVYSCPFDGM ITETKGTVLI KTAEELMNFS KGEENLMDAQ VKAIAGTGAN VIVTGGKVAD 240
IALHYANKYN IMLVRLNSKW DLRRLCKTVG ATALPKLTPP VQEEMGHCDS VYLSEVGDTQ 300
VVVFKHEKED GAISTIVLRG STDNLMDDIE RAVDDGVNTF KVLTRDKRLV PGGGATEIEL 360
AKQITSYGET CPGLEQYAIK KFAEAFEAIP RALAENSGVK ANEVISKLYS VHQEGNKNVG 420
LDIEAEVPAV KDMLEASILD TYLGKYWAIK LATNAAVTVL RVDQIIMAKP AGGPKPPSGK 480
KDWDDDQND 489 
Gene Ontology
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0002199; C:zona pellucida receptor complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007339; P:binding of sperm to zona pellucida; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012721; Chap_CCT_theta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.