CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021211
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 COMM domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 COMMD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29LAKMSSVKLRLLCSQubiquitination[1]
39LLCSQVLKELLGQGIubiquitination[2]
50GQGIDYEKILKLTADubiquitination[1, 2, 3, 4, 5]
53IDYEKILKLTADAKFubiquitination[1, 2, 4]
59LKLTADAKFESGDVKubiquitination[1, 2, 3, 5]
100LQQLGLPKEHAASLCubiquitination[2]
113LCRCYEEKQSPLQKHubiquitination[2]
119EKQSPLQKHLRVCSLubiquitination[1, 2]
180AMSLSADKFQVLLAEubiquitination[1, 2, 6]
189QVLLAELKQAQTLMSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
 Down-regulates activation of NF-kappa-B. 
Sequence Annotation
 DOMAIN 130 199 COMM.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 199 AA 
Protein Sequence
MRFRFCGDLD CPDWVLAEIS TLAKMSSVKL RLLCSQVLKE LLGQGIDYEK ILKLTADAKF 60
ESGDVKATVA VLSFILSSAA KHSVDGESLS SELQQLGLPK EHAASLCRCY EEKQSPLQKH 120
LRVCSLRMNR LAGVGWRVDY TLSSSLLQSV EEPMVHLRLE VAAAPGTPAQ PVAMSLSADK 180
FQVLLAELKQ AQTLMSSLG 199 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:LIFEdb. 
Interpro
 IPR017920; COMM.
 IPR009886; HCaRG. 
Pfam
 PF07258; HCaRG 
SMART
  
PROSITE
 PS51269; COMM 
PRINTS