CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044050
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger E-box-binding homeobox 2 
Protein Synonyms/Alias
  
Gene Name
 Zeb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
376RNKLENGKPLSMSEQacetylation[1]
642LSSVLSEKGLTSPINubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1214 AA 
Protein Sequence
MKQPIMADGP RCKRRKQANP RRKNVVNYDN VVDAGSETDE EDKLHIAEDD SLANPLDQDT 60
SPASMPNHES SPHMSQGLLP REEEEEELRE SVVEHSWHSG EILQASVAGP EMKEDYDAMG 120
PEATIQTTIN NGTVKNANCT SDFEEYFAKR KLEERDGHAV SIEEYLQRSD TAIIYPEAPE 180
ELSRLGTPEA NGQEENDLPP GTPDAFAQLL TCPYCDRGYK RLTSLKEHIK YRHEKNEENF 240
SCPLCSYTFA YRTQLERHMV THKPGTDQHQ MLTQGAGNRK FKCTECGKAF KYKHHLKEHL 300
RIHSGEKPYE CPNCKKRFSH SGSYSSHISS KKCIGLISVN GRMRNNIKTG SSPNSVSSSP 360
TNSAITQLRN KLENGKPLSM SEQTGLLKIK TEPLDFNDYK VLMATHGFSG SSPFMNGGLG 420
ATSPLGVHPS AQSPMQHLGV GMEAPLLGFP TMNSNLSEVQ KVLQIVDNTV SRQKMDCKTE 480
DISKLKGYHM KDPCSQPEEQ GVTSPNIPPV GLPVVSHNGA TKSIIDYTLE KVNEAKACLQ 540
SLTTDSRRQI SNIKKEKLRT LIDLVTDDKM IENHSISTPF SCQFCKESFP GPIPLHQHER 600
YLCKMNEEIK AVLQPHENIV PNKAGVFVDN KALLLSSVLS EKGLTSPINP YKDHMSVLKA 660
YYAMNMEPNS DELLKISIAV GLPQEFVKEW FEQRKVYQYS NSRSPSLERT SKPLAPNSNP 720
TTKDSLLPRS PVKPMDSITS PSIAELHNSV TSCDPPLRLT KSSHFTNIKA VDKLDHSRSN 780
TPSPLNLSST SSKNSHSSSY TPNSFSSEEL QAEPLDLSLP KQMREPKGII ATKNKTKATS 840
INLDHNSVSS SSENSDEPLN LTFIKKEFSN SNNLDNKSNN PVFGMNPFSA KPLYTPLPPQ 900
SAFPPATFMP PVQTSIPGLR PYPGLDQMSF LPHMAYTYPT GAATFADMQQ RRKYQRKQGF 960
QGDLLDGAQD YMSGLDDMTD SDSCLSRKKI KKTESGMYAC DLCDKTFQKS SSLLRHKYEH 1020
TGKRPHQCQI CKKAFKHKHH LIEHSRLHSG EKPYQCDKCG KRFSHSGSYS QHMNHRYSYC 1080
KREAEEREAA EREAREKGHL EPTELLMNRA YLQSITPQGY SDSEERESMP RDGESEKEHE 1140
KEGEEGYGKL RRRDGDEEEE EEEEESENKS MDTDPETIRD EEETGDHSMD DSSEDGKMET 1200
KSDHEEDNME DGME 1214 
Gene Ontology
 GO:0070412; F:R-SMAD binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0021846; P:cell proliferation in forebrain; IMP:MGI.
 GO:0021766; P:hippocampus development; IMP:MGI.
 GO:0001755; P:neural crest cell migration; IMP:MGI.
 GO:0001843; P:neural tube closure; IMP:MGI.
 GO:0043507; P:positive regulation of JUN kinase activity; IMP:MGI.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IMP:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI. 
Interpro
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00389; HOX
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS