UniProt Accession

 SHCBP_HUMAN; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6 

Genbank Protein ID

 AK025662; AK055931; AC092368; BC000960; BC030699 

Genbank Nucleotide ID

 BAB15208.1; BAB71049.1; AAH00960.1; AAH30699.1 

Protein Name

 SHC SH2 domain-binding protein 1 

Protein Synonyms/Alias

  

Gene Name

 SHCBP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	SDCSYRDKPGSSLQS	ubiquitination	[1, 2]
94	DYILADCKASEVQEF	ubiquitination	[3]
139	DVDFAALKAVVRLAE	ubiquitination	[1]
296	YSEMEQLKQKLKLIE	ubiquitination	[1, 2, 3]
300	EQLKQKLKLIENPLL	ubiquitination	[1, 2, 3, 4]
315	RYVFGYQKNSNIQAK	ubiquitination	[1, 2, 5]
419	IVIEKRGKGDTFVDC	ubiquitination	[1, 2, 4]
454	ILIVHRGKTTLENCV	ubiquitination	[2]
480	TSAEFLMKNSDLYGA	ubiquitination	[2]
488	NSDLYGAKGAGIEIY	ubiquitination	[2]
517	CKEGILIKDFLDEHY	ubiquitination	[2]
664	NQFKWNGKGSFGTFL	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells (By similarity). 

Sequence Annotation

 REPEAT 428 451 PbH1 1.
 REPEAT 452 473 PbH1 2.
 REPEAT 474 496 PbH1 3.
 REPEAT 497 518 PbH1 4.
 REPEAT 526 548 PbH1 5.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 7 7 Phosphothreonine.
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 273 273 Phosphoserine.
 MOD_RES 634 634 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 672 AA 

Protein Sequence

Gene Ontology

 GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:2000177; P:regulation of neural precursor cell proliferation; ISS:UniProtKB. 

Interpro

 IPR006626; PbH1.
 IPR012334; Pectin_lyas_fold.
 IPR011050; Pectin_lyase_fold/virulence. 

Pfam

  

SMART

 SM00710; PbH1 

PROSITE

  

PRINTS