UniProt Accession

 RS19_ECOLI; P0A7U3; P02375; Q2M6Y1 

Genbank Protein ID

 X02613; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA26464.1; AAA58113.1; AAC76341.1; BAE77975.1 

Protein Name

 30S ribosomal protein S19 

Protein Synonyms/Alias

  

Gene Name

 rpsS 

Gene Synonyms/Alias

 b3316; JW3278 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
17	FIDLHLLKKVEKAVE	acetylation	[1]
18	IDLHLLKKVEKAVES	acetylation	[1]
21	HLLKKVEKAVESGDK	acetylation	[2]
28	KAVESGDKKPLRTWS	acetylation	[1, 2]
29	AVESGDKKPLRTWSR	acetylation	[1, 2]
70	TDEMVGHKLGEFAPT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 In the E.coli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed:12859903), contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures (PubMed:16272117) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding; tRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 92 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:EcoliWiki.
 GO:0019843; F:rRNA binding; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR002222; Ribosomal_S19.
 IPR005732; Ribosomal_S19_bac-type.
 IPR020934; Ribosomal_S19_CS.
 IPR023575; Ribosomal_S19_SF. 

Pfam

 PF00203; Ribosomal_S19 

SMART

  

PROSITE

 PS00323; RIBOSOMAL_S19 

PRINTS

 PR00975; RIBOSOMALS19.