CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Vesicle-associated membrane protein 8 
Protein Synonyms/Alias
  
Gene Name
 VAMP8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21NLEHLRNKTEDLEATubiquitination[1, 2, 3, 4]
33EATSEHFKTTSQKVAubiquitination[1, 2, 3]
38HFKTTSQKVARKFWWubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 74 AA 
Protein Sequence
MTQNVERILA RGENLEHLRN KTEDLEATSE HFKTTSQKVA RKFWWKNVKM IVLICVIVFI 60
IILFIVLFAT GAFS 74 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0031902; C:late endosome membrane; IEA:Compara.
 GO:0005765; C:lysosomal membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0055037; C:recycling endosome; IEA:Compara.
 GO:0030141; C:secretory granule; IEA:Compara.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0030100; P:regulation of endocytosis; IEA:Compara.
 GO:0006906; P:vesicle fusion; IEA:Compara. 
Interpro
 IPR001388; Synaptobrevin. 
Pfam
 PF00957; Synaptobrevin 
SMART
  
PROSITE
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 
PRINTS
 PR00219; SYNAPTOBREVN.