CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030310
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Excision repair cross-complementing rodent repair deficiency, complementation group 5 
Protein Synonyms/Alias
  
Gene Name
 Ercc5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
209HEILTDMKEFTKRRRubiquitination[1]
912AENPYDTKVKKKLRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Nucleus. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1170 AA 
Protein Sequence
MGVQGLWKLL ECSGHRVSPE ALEGKVLAVD ISIWLNQALK GVRDSHGNVI ENAHLLTLFH 60
RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRQRKDSASI DSRKTTEKLL KTFLKRQALK 120
TAFRSSRHEA PPSLTQVQRQ DDIYVLPPLP EEEKHSSEEE DEKQWQARMD QKQALQEEFF 180
HNPQAIDIES EDFSSLPPEV KHEILTDMKE FTKRRRTLFE AMPEESNDFS QYQLKGLLKK 240
NYLNQHIENV QKEMNQQHSG QIQRQYQDEG GFLKEVESRR VVSEDTSHYI LIKGIQGKKV 300
MDVDSESLPS SSNVHSVSSN LKSSPHEKVK PEREPEAAPP SPRTLLAIQA AMLGSSSEDE 360
PESREGRQSK ERNSGATADA GSISPRTRAA IQKALDDDND EKVSGSSDDL AEKMLLGSRL 420
EQEEHADETA ERGGGVPFDT APLTPSVTEV KECVTSGSSA NEQTDSAHSF TTASHRCDTP 480
KETVSLARAV KEASQISSEC EVEGRPAALS PAFIGTPSSH VSGVLSEREP TLAPPTTRTH 540
SDQGLDIHPE DPELQNGLYP PESKCNSSRL SSDDETEGGQ NPAPKACSTV HVPAEAMSNL 600
ENALPSNAEE RGDFQETIQL REVPEAAARE LISAPKPMGP MEMESEESES DGSFIEVQSV 660
VSNSELQTES SEASTHLSEK DAEEPREILE EGTSRDTECL LQDSSDIEAM EGHREADIDA 720
EDMPNEWQDI NLEELDALES NLLAEQNSLK AQKQQQDRIA ASVTGQMFLE SQELLRLFGV 780
PYIQAPMEAE AQCAMLDLTD QTSGTITDDS DIWLFGARHV YKNFFNKNKF VEYYQYVDFY 840
SQLGLDRNKL INLAYLLGSD YTEGIPTVGC VTAMEILNEF PGRGLDPLLK FSEWWHEAQN 900
NKKVAENPYD TKVKKKLRKL QLTPGFPNPA VADAYLRPVV DDSRGSFLWG KPDVDKIREF 960
CQRYFGWNRM KTDESLYPVL KHLNAHQTQL RIDSFFRLAQ QEKQDAKLIK SHRLSRAVTC 1020
MLRKEREEKA PELTKVTEAL DDAKGKTQKR ELPYKKETSV PKRRRPSGNG GFLGDPYCSE 1080
SPQESSCEDG EGSSVMSARQ RSAAESSKIG CSDVPDLVRD SPHGRQGCVS TSSSSEDGED 1140
KAKTVLVTAR PVFGKKKLKL KSMKRRKKKT 1170 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
 GO:0008340; P:determination of adult lifespan; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006289; P:nucleotide-excision repair; IMP:MGI.
 GO:0009650; P:UV protection; IDA:MGI. 
Interpro
 IPR020045; 5-3_exonuclease_C.
 IPR008918; HhH2.
 IPR006086; XPG-I_dom.
 IPR006084; XPG/Rad2.
 IPR001044; XPG/Rad2_eukaryotes.
 IPR019974; XPG_CS.
 IPR006085; XPG_DNA_repair_N. 
Pfam
 PF00867; XPG_I
 PF00752; XPG_N 
SMART
 SM00279; HhH2
 SM00484; XPGI
 SM00485; XPGN 
PROSITE
 PS00841; XPG_1
 PS00842; XPG_2 
PRINTS
 PR00853; XPGRADSUPER.
 PR00066; XRODRMPGMNTG.