CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate decarboxylase 1 
Protein Synonyms/Alias
 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform 
Gene Name
 Gad1 
Gene Synonyms/Alias
 Gad67 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
470FWLMWKAKGTVGFENubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Catalyzes the production of GABA. 
Sequence Annotation
 REGION 189 191 Substrate binding (By similarity).
 BINDING 566 566 Substrate (By similarity).
 MOD_RES 404 404 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Decarboxylase; Lyase; Neurotransmitter biosynthesis; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MASSTPSPAT SSNAGADPNT TNLRPTTYDT WCGVAHGCTR KLGLKICGFL QRTNSLEEKS 60
RLVSAFRERQ SSKNLLSCEN SDQGARFRRT ETDFSNLFAQ DLLPAKNGEE QTAQFLLEVV 120
DILLNYVRKT FDRSTKVLDF HHPHQLLEGM EGFNLELSDH PESLEQILVD CRDTLKYGVR 180
TGHPRFFNQL STGLDIIGLA GEWLTSTANT NMFTYEIAPV FVLMEQITLK KMREIVGWSN 240
KDGDGIFSPG GAISNMYSIM AARYKYFPEV KTKGMAAVPK LVLFTSEHSH YSIKKAGAAL 300
GFGTDNVILI KCNERGKIIP ADLEAKILDA KQKGYVPLYV NATAGTTVYG AFDPIQEIAD 360
ICEKYNLWLH VDAAWGGGLL MSRKHRHKLS GIERANSVTW NPHKMMGVLL QCSAILVKEK 420
GILQGCNQMC AGYLFQPDKQ YDVSYDTGDK AIQCGRHVDI FKFWLMWKAK GTVGFENQIN 480
KCLELADYLY AKIKNREEFE MVFDGEPEHT NVCFWYIPQS LRGVPDSPER REKLHRVAPK 540
IKALMMESGT TMVGYQPQGD KANFFRMVIS NPAATQSDID FLIEEIERLG QDL 593 
Gene Ontology
 GO:0043679; C:axon terminus; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0048786; C:presynaptic active zone; IDA:MGI.
 GO:0004351; F:glutamate decarboxylase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0048854; P:brain morphogenesis; IMP:MGI.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
 GO:0021696; P:cerebellar cortex morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0035108; P:limb morphogenesis; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0061351; P:neural precursor cell proliferation; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
 GO:0021772; P:olfactory bulb development; IMP:MGI. 
Interpro
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR021115; Pyridoxal-P_BS. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
 PS00392; DDC_GAD_HDC_YDC 
PRINTS