UniProt Accession

 YFCE_ECOLI; P67095; P76495; Q2MAL9 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC75360.1; BAE76687.1 

Protein Name

 Phosphodiesterase YfcE 

Protein Synonyms/Alias

  

Gene Name

 yfcE 

Gene Synonyms/Alias

 b2300; JW5377 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
55	PEGYAPAKVAERLNE	acetylation	[1]
66	RLNEVAHKVIAVRGN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p- nitrophenylphosphorylcholine (pNPPC). The physiological substrate is unknown. 

Sequence Annotation

 METAL 9 9 Manganese 1.
 METAL 11 11 Manganese 1.
 METAL 37 37 Manganese 1.
 METAL 37 37 Manganese 2.
 METAL 73 73 Manganese 2.
 METAL 105 105 Manganese 2.
 METAL 127 127 Manganese 2.
 METAL 129 129 Manganese 1.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Manganese; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR020935; PdiEstase_YfcE_CS.
 IPR000979; Phosphodiesterase_MJ0936. 

Pfam

 PF00149; Metallophos 

SMART

  

PROSITE

 PS01269; UPF0025 

PRINTS