UniProt Accession

 IMDH4_YEAST; P50094; D6VZB8; Q2VQW8 

Genbank Protein ID

 Z46729; AY899250; BK006946 

Genbank Nucleotide ID

 CAA86719.1; AAX83935.1; DAA09842.1 

Protein Name

 Inosine-5'-monophosphate dehydrogenase 4 

Protein Synonyms/Alias

 IMP dehydrogenase 4; IMPD 4; IMPDH 4 

Gene Name

 IMD4 

Gene Synonyms/Alias

 YML056C; YM9958.06C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
16	KKALEHLKTYSSKDG	acetylation	[1]
144	EVKVMKRKFGFSGFP	acetylation	[1]
161	EDGKCPGKLVGLVTS	acetylation	[1]
194	KNPVTGIKGITLKEG	acetylation	[1]
408	SPGEYFYKDGKRLKA	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). 

Sequence Annotation

 DOMAIN 122 183 CBS 1.
 DOMAIN 185 241 CBS 2.
 NP_BIND 279 281 NAD (By similarity).
 NP_BIND 329 331 NAD (By similarity).
 REGION 369 371 IMP binding (By similarity).
 REGION 392 393 IMP binding (By similarity).
 REGION 416 420 IMP binding (By similarity).
 ACT_SITE 336 336 Thioimidate intermediate (By similarity).
 METAL 331 331 Potassium; via carbonyl oxygen (By
 METAL 333 333 Potassium; via carbonyl oxygen (By
 METAL 336 336 Potassium; via carbonyl oxygen (By
 METAL 509 509 Potassium; via carbonyl oxygen; shared
 METAL 510 510 Potassium; via carbonyl oxygen; shared
 METAL 511 511 Potassium; via carbonyl oxygen; shared
 BINDING 334 334 IMP (By similarity).
 BINDING 450 450 IMP (By similarity).
 MOD_RES 125 125 Phosphoserine.  

Keyword

 CBS domain; Complete proteome; Cytoplasm; GMP biosynthesis; Metal-binding; NAD; Oxidoreductase; Phosphoprotein; Potassium; Purine biosynthesis; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0003938; F:IMP dehydrogenase activity; ISS:SGD.
 GO:0046872; F:metal ion binding; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:HAMAP.
 GO:0006177; P:GMP biosynthetic process; IEA:HAMAP. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR000644; Cysta_beta_synth_core.
 IPR005990; IMP_DH.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 

Pfam

 PF00571; CBS
 PF00478; IMPDH 

SMART

 SM00116; CBS 

PROSITE

 PS51371; CBS
 PS00487; IMP_DH_GMP_RED 

PRINTS