| Tag | Content |
|---|
| CPLM ID | CPLM-018730 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SMG7 |
Protein Synonyms/Alias | EST1-like protein C; SMG-7 homolog; hSMG-7 |
Gene Name | SMG7 |
Gene Synonyms/Alias | C1orf16; EST1C; KIAA0250 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 54 | DLEYALDKKVEQDLW | ubiquitination | [1] | | 910 | MFNEVYGKNLTSSSK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. |
Sequence Annotation | REPEAT 152 185 TPR 1.
REPEAT 187 219 TPR 2.
MOD_RES 2 2 N-acetylserine.
MOD_RES 520 520 Phosphoserine.
MOD_RES 781 781 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1137 AA |
Protein Sequence | MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 60
WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 120
VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 180
LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 240
KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 300
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 360
LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 420
LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 480
GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 540
EKPVVTFKEN IKTREVNRDQ GRSFPPKEVK SQTELRKTPV SEARKTPVTQ TPTQASNSQF 600
IPIHHPGAFP PLPSRPGFPP PTYVIPPPVA FSMGSGYTFP AGVSVPGTFL QPTAHSPAGN 660
QVQAGKQSHI PYSQQRPSGP GPMNQGPQQS QPPSQQPLTS LPAQPTAQST SQLQVQALTQ 720
QQQSPTKAVP ALGKSPPHHS GFQQYQQADA SKQLWNPPQV QGPLGKIMPV KQPYYLQTQD 780
PIKLFEPSLQ PPVMQQQPLE KKMKPFPMEP YNHNPSEVKV PEFYWDSSYS MADNRSVMAQ 840
QANIDRRGKR SPGVFRPEQD PVPRMPFEKS LLEKPSELMS HSSSFLSLTG FSLNQERYPN 900
NSMFNEVYGK NLTSSSKAEL SPSMAPQETS LYSLFEGTPW SPSLPASSDH STPASQSPHS 960
SNPSSLPSSP PTHNHNSVPF SNFGPIGTPD NRDRRTADRW KTDKPAMGGF GIDYLSATSS 1020
SESSWHQAST PSGTWTGHGP SMEDSSAVLM ESLKSIWSSS MMHPGPSALE QLLMQQKQKQ 1080
QRGQGTMNPP H 1091 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA. GO:0005634; C:nucleus; IDA:HGNC. GO:0051721; F:protein phosphatase 2A binding; IDA:HGNC. GO:0010467; P:gene expression; TAS:Reactome. GO:0006406; P:mRNA export from nucleus; TAS:HGNC. GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:HGNC. GO:0035303; P:regulation of dephosphorylation; TAS:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |