CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MDS1 and EVI1 complex locus protein EVI1 
Protein Synonyms/Alias
 Ecotropic virus integration site 1 protein homolog; EVI-1 
Gene Name
 MECOM 
Gene Synonyms/Alias
 EVI1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
564TTKRKDEKPLTPVPSacetylation[1]
Reference
 [1] Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.
 Shimahara A, Yamakawa N, Nishikata I, Morishita K.
 J Biol Chem. 2010 May 28;285(22):16967-77. [PMID: 20363750] 
Functional Description
 Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. 
Sequence Annotation
 ZN_FING 21 44 C2H2-type 1.
 ZN_FING 75 97 C2H2-type 2.
 ZN_FING 103 125 C2H2-type 3.
 ZN_FING 131 154 C2H2-type 4.
 ZN_FING 160 182 C2H2-type 5.
 ZN_FING 188 210 C2H2-type 6.
 ZN_FING 217 239 C2H2-type 7.
 ZN_FING 733 755 C2H2-type 8.
 ZN_FING 761 784 C2H2-type 9.
 ZN_FING 790 812 C2H2-type 10.
 REGION 1 252 Interaction with MAPK9, SMAD3 and
 MOTIF 421 434 Nuclear localization signal (Potential).
 MOTIF 553 557 CTBP-binding motif 1 (By similarity).
 MOTIF 584 588 CTBP-binding motif 2 (By similarity).
 MOD_RES 854 854 Phosphoserine (By similarity).
 MOD_RES 858 858 Phosphoserine (By similarity).
 MOD_RES 860 860 Phosphoserine.  
Keyword
 Acetylation; Alternative promoter usage; Alternative splicing; Apoptosis; Chromosomal rearrangement; Complete proteome; Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1051 AA 
Protein Sequence
MKSEDYPHET MAPDIHEERQ YRCEDCDQLF ESKAELADHQ KFPCSTPHSA FSMVEEDFQQ 60
KLESENDLQE IHTIQECKEC DQVFPDLQSL EKHMLSHTEE REYKCDQCPK AFNWKSNLIR 120
HQMSHDSGKH YECENCAKVF TDPSNLQRHI RSQHVGARAH ACPECGKTFA TSSGLKQHKH 180
IHSSVKPFIC EVCHKSYTQF SNLCRHKRMH ADCRTQIKCK DCGQMFSTTS SLNKHRRFCE 240
GKNHFAAGGF FGQGISLPGT PAMDKTSMVN MSHANPGLAD YFGANRHPAG LTFPTAPGFS 300
FSFPGLFPSG LYHRPPLIPA SSPVKGLSST EQTNKSQSPL MTHPQILPAT QDILKALSKH 360
PSVGDNKPVE LQPERSSEER PFEKISDQSE SSDLDDVSTP SGSDLETTSG SDLESDIESD 420
KEKFKENGKM FKDKVSPLQN LASINNKKEY SNHSIFSPSL EEQTAVSGAV NDSIKAIASI 480
AEKYFGSTGL VGLQDKKVGA LPYPSMFPLP FFPAFSQSMY PFPDRDLRSL PLKMEPQSPG 540
EVKKLQKGSS ESPFDLTTKR KDEKPLTPVP SKPPVTPATS QDQPLDLSMG SRSRASGTKL 600
TEPRKNHVFG GKKGSNVESR PASDGSLQHA RPTPFFMDPI YRVEKRKLTD PLEALKEKYL 660
RPSPGFLFHP QFQLPDQRTW MSAIENMAEK LESFSALKPE ASELLQSVPS MFNFRAPPNA 720
LPENLLRKGK ERYTCRYCGK IFPRSANLTR HLRTHTGEQP YRCKYCDRSF SISSNLQRHV 780
RNIHNKEKPF KCHLCDRCFG QQTNLDRHLK KHENGNMSGT ATSSPHSELE STGAILDDKE 840
DAYFTEIRNF IGNSNHGSQS PRNVEERMNG SHFKDEKALV TSQNSDLLDD EEVEDEVLLD 900
EEDEDNDITG KTGKEPVTSN LHEGNPEDDY EETSALEMSC KTSPVRYKEE EYKSGLSALD 960
HIRHFTDSLK MRKMEDNQYS EAELSSFSTS HVPEELKQPL HRKSKSQAYA MMLSLSDKES 1020
LHSTSHSSSN VWHSMARAAA ESSAIQSISH V 1051 
Gene Ontology
 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0071425; P:hematopoietic stem cell proliferation; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0046329; P:negative regulation of JNK cascade; IMP:UniProtKB.
 GO:0043069; P:negative regulation of programmed cell death; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0001780; P:neutrophil homeostasis; IEA:Compara.
 GO:0060039; P:pericardium development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IDA:UniProtKB.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0072001; P:renal system development; IEA:Compara.
 GO:0009617; P:response to bacterium; IEA:Compara.
 GO:0009605; P:response to external stimulus; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS