UniProt Accession

 ADDB_HUMAN; P35612; A8K4P2; B4DM17; D6W5G7; D6W5G8; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691 

Genbank Protein ID

 X58199; AF486420; AF486421; AF486422; AF486423; AK291007; AK297250; AB209227; AB593080; AC005234; AC007395; CH471053; CH471053; CH471053; CH471053; BC041666; BC051882; BC056881; BC065525; U43959; S81079; S81077 

Genbank Nucleotide ID

 CAA41176.1; AAP71863.1; AAP71864.1; AAP71865.1; AAP71866.1; BAF83696.1; BAG59729.1; BAD92464.1; BAJ84020.1; AAD12715.1; EAW99801.1; EAW99806.1; EAW99807.1; EAW99808.1; AAH41666.1; AAH51882.1; AAH56881.1; AAH65525.1; AAA86421.1; AAD14349.1; AAD14349.1 

Protein Name

 Beta-adducin 

Protein Synonyms/Alias

 Erythrocyte adducin subunit beta 

Gene Name

 ADD2 

Gene Synonyms/Alias

 ADDB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
576	KKEVERKKLELDGEK	acetylation	[1]
583	KLELDGEKETAPEEP	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. 

Sequence Annotation

 REGION 425 444 Interaction with calmodulin (Potential).
 REGION 704 721 Interaction with calmodulin (Potential).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 55 55 Phosphothreonine; by PKA.
 MOD_RES 530 530 Phosphoserine.
 MOD_RES 532 532 Phosphoserine (By similarity).
 MOD_RES 535 535 Phosphoserine (By similarity).
 MOD_RES 561 561 Phosphothreonine (By similarity).
 MOD_RES 592 592 Phosphoserine.
 MOD_RES 596 596 Phosphoserine.
 MOD_RES 600 600 Phosphoserine.
 MOD_RES 604 604 Phosphoserine.
 MOD_RES 611 611 Phosphothreonine.
 MOD_RES 613 613 Phosphoserine.
 MOD_RES 617 617 Phosphoserine.
 MOD_RES 688 688 Phosphothreonine (By similarity).
 MOD_RES 693 693 Phosphoserine.
 MOD_RES 697 697 Phosphoserine.
 MOD_RES 703 703 Phosphoserine; by PKC.
 MOD_RES 713 713 Phosphoserine; by PKA and PKC.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 726 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.
 GO:0008290; C:F-actin capping protein complex; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0051015; F:actin filament binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0030507; F:spectrin binding; IDA:BHF-UCL.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0051017; P:actin filament bundle assembly; IDA:BHF-UCL.
 GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IDA:BHF-UCL.
 GO:0006461; P:protein complex assembly; IDA:UniProtKB. 

Interpro

 IPR001303; Aldolase_II/adducin_N. 

Pfam

 PF00596; Aldolase_II 

SMART

 SM01007; Aldolase_II 

PROSITE

  

PRINTS