CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor of activated T-cells, cytoplasmic 1 
Protein Synonyms/Alias
 NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc 
Gene Name
 NFATC1 
Gene Synonyms/Alias
 NFAT2; NFATC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
349QPPSVALKVEPVGEDsumoylation[1]
538IDCAGILKLRNSDIEubiquitination[2]
702PANVPIIKTEPTDDYsumoylation[1]
914APIPVTVKREPEELDsumoylation[1]
Reference
 [1] Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.
 Nayak A, Glöckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F.
 J Biol Chem. 2009 Apr 17;284(16):10935-46. [PMID: 19218564]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. 
Sequence Annotation
 REPEAT 203 219 1.
 REPEAT 233 249 2.
 REPEAT 282 298 3.
 DOMAIN 410 592 RHD.
 DNA_BIND 439 446
 REGION 118 123 Calcineurin-binding.
 REGION 126 218 Trans-activation domain A (TAD-A).
 REGION 203 298 3 X SP repeats.
 REGION 703 943 Trans-activation domain B (TAD-B).
 MOTIF 265 267 Nuclear localization signal.
 MOTIF 310 321 Nuclear export signal.
 MOTIF 682 684 Nuclear localization signal.
 MOTIF 924 933 Nuclear export signal.
 MOD_RES 245 245 Phosphoserine; by PKA.
 MOD_RES 269 269 Phosphoserine; by PKA.
 MOD_RES 294 294 Phosphoserine; by PKA.  
Keyword
 3D-structure; Activator; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 943 AA 
Protein Sequence
MPSTSFPVPS KFPLGPAAAV FGRGETLGPA PRAGGTMKSA EEEHYGYASS NVSPALPLPT 60
AHSTLPAPCH NLQTSTPGII PPADHPSGYG AALDGGPAGY FLSSGHTRPD GAPALESPRI 120
EITSCLGLYH NNNQFFHDVE VEDVLPSSKR SPSTATLSLP SLEAYRDPSC LSPASSLSSR 180
SCNSEASSYE SNYSYPYASP QTSPWQSPCV SPKTTDPEEG FPRGLGACTL LGSPRHSPST 240
SPRASVTEES WLGARSSRPA SPCNKRKYSL NGRQPPYSPH HSPTPSPHGS PRVSVTDDSW 300
LGNTTQYTSS AIVAAINALT TDSSLDLGDG VPVKSRKTTL EQPPSVALKV EPVGEDLGSP 360
PPPADFAPED YSSFQHIRKG GFCDQYLAVP QHPYQWAKPK PLSPTSYMSP TLPALDWQLP 420
SHSGPYELRI EVQPKSHHRA HYETEGSRGA VKASAGGHPI VQLHGYLENE PLMLQLFIGT 480
ADDRLLRPHA FYQVHRITGK TVSTTSHEAI LSNTKVLEIP LLPENSMRAV IDCAGILKLR 540
NSDIELRKGE TDIGRKNTRV RLVFRVHVPQ PSGRTLSLQV ASNPIECSQR SAQELPLVEK 600
QSTDSYPVVG GKKMVLSGHN FLQDSKVIFV EKAPDGHHVW EMEAKTDRDL CKPNSLVVEI 660
PPFRNQRITS PVHVSFYVCN GKRKRSQYQR FTYLPANVPI IKTEPTDDYE PAPTCGPVSQ 720
GLSPLPRPYY SQQLAMPPDP SSCLVAGFPP CPQRSTLMPA APGVSPKLHD LSPAAYTKGV 780
ASPGHCHLGL PQPAGEAPAV QDVPRPVATH PGSPGQPPPA LLPQQVSAPP SSSCPPGLEH 840
SLCPSSPSPP LPPATQEPTC LQPCSPACPP ATGRPQHLPS TVRRDESPTA GPRLLPEVHE 900
DGSPNLAPIP VTVKREPEEL DQLYLDDVNE IIRNDLSSTS THS 943 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0005528; F:FK506 binding; TAS:ProtInc.
 GO:0048273; F:mitogen-activated protein kinase p38 binding; ISS:BHF-UCL.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0001205; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:BHF-UCL.
 GO:0001085; F:RNA polymerase II transcription factor binding; ISS:BHF-UCL.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0001837; P:epithelial to mesenchymal transition; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IDA:MGI. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR008366; NFAT.
 IPR015647; NFAT1.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 
Pfam
 PF00554; RHD
 PF01833; TIG 
SMART
 SM00429; IPT 
PROSITE
 PS01204; REL_1
 PS50254; REL_2 
PRINTS
 PR01789; NUCFACTORATC.