CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042050
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myosin-14 
Protein Synonyms/Alias
  
Gene Name
 MYH14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
103IQRMNPPKFSKAEDMubiquitination[1]
260LEAFGNAKTVKNDNSubiquitination[1]
441YVQKAQTKEQADFALubiquitination[2]
1510TLEKKQRKFDQLLAEubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2036 AA 
Protein Sequence
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW TARRLVWVPS 60
ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN PPKFSKAEDM AELTCLNEAS 120
VLHNLRERYY SGLIYTYSGL FCVVINPYKQ LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG 180
AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PVSNPALGWG 240
ELERQLLQAN PILEAFGNAK TVKNDNSSRF GKFIRINFDV AGYIVGANIE TYLLEKSRAI 300
RQAKDECSFH IFYQLLGGAG EQLKADLLLE PCSHYRFLTN GPSSSPGQER ELFQETLESL 360
RVLGFSHEEI ISMLRMVSAV LQFGNIALKR ERNTDQATMP DNTAAQKLCR LLGLGVTDFS 420
RALLTPRIKV GRDYVQKAQT KEQADFALEA LAKATYERLF RWLVLRLNRA LDRSPRQGAS 480
FLGILDIAGF EIFQLNSFEQ LCINYTNEKL QQLFNHTMFV LEQEEYQREG IPWTFLDFGL 540
DLQPCIDLIE RPANPPGLLA LLDEECWFPK ATDKSFVEKV AQEQGGHPKF QRPRHLRDQA 600
DFSVLHYAGK VDYKANEWLM KNMDPLNDNV AALLHQSTDR LTAEIWKDEH GGFQQFSFLG 660
SFPPSPPGSA ERCSSAISPP GVEGIVGLEQ VSSLGDGPPG GRPRRGMFRT VGQLYKESLS 720
RLMATLSNTN PSFVRCIVPN HEKRAGKLEP RLVLDQLRCN GVLEGIRICR QGFPNRILFQ 780
EFRQRYEILT PNAIPKGFMD GKQACEKMIQ ALELDPNLYR VGQSKIFFRA GVLAQLEEER 840
DLKVTDIIVS FQAAARGYLA RRAFQKRQQQ QSALRVMQRN CAAYLKLRHW QWWRLFTKVK 900
PLLQVTRQDE VLQARAQELQ KVQELQQQSA REVGELQGRV AQLEEERARL AEQLRAEAEL 960
CAEAEETRGR LAARKQELEL VVSELEARVG EEEECSRQMQ TEKKRLQQHI QELEAHLEAE 1020
EGARQKLQLE KVTTEAKMKK FEEDLLLLED QNSKLSKERK LLEDRLAEFS SQAAEEEEKV 1080
KSLNKLRLKY EATIADMEDR LRKEEKGRQE LEKLKRRLDG ESSELQEQMV EQQQRAEELR 1140
AQLGRKEEEL QAALARAEDE GGARAQLLKS LREAQAALAE AQEDLESERV ARTKAEKQRR 1200
DLGEELEALR GELEDTLDST NAQQELRSKR EQEVTELKKT LEEETRIHEA AVQELRQRHG 1260
QALGELAEQL EQARRGKGAW EKTRLALEAE VSELRAELSS LQTARQEGEQ RRRRLELQLQ 1320
EVQGRAGDGE RARAEAAEKL QRAQAELENV SGALNEAESK TIRLSKELSS TEAQLHDAQE 1380
LLQEETRAKL ALGSRVRAME AEAAGLREQL EEEAAARERA GRELQTAQAQ LSEWRRRQEE 1440
EAGALEAGEE ARRRAAREAE ALTQRLAEKT ETVDRLERGR RRLQQELDDA TMDLEQQRQL 1500
VSTLEKKQRK FDQLLAEEKA AVLRAVEERE RAEAEGRERE ARALSLTRAL EEEQEAREEL 1560
ERQNRALRAE LEALLSSKDD VGKSVHELER ACRVAEQAAN DLRAQVTELE DELTAAEDAK 1620
LRLEVTVQAL KTQHERDLQG RDEAGEERRR QLAKQLRDAE VERDEERKQR TLAVAARKKL 1680
EGELEELKAQ MASAGQGKEE AVKQLRKMQA QMKELWREVE ETRTSREEIF SQNRESEKRL 1740
KGLEAEVLRL QEELAASDRA RRQAQQDRDE MADEVANGNL SKAAILEEKR QLEGRLGQLE 1800
EELEEEQSNS ELLNDRYRKL LLQVESLTTE LSAERSFSAK AESGRQQLER QIQELRGRLG 1860
EEDAGARARH KMTIAALESK LAQAEEQLEQ ETRERILSGK LVRRAEKRLK EVVLQVEEER 1920
RVADQLRDQL EKGNLRVKQL KRQLEEAEEE ASRAQAGRRR LQRELEDVTE SAESMNREVT 1980
TLRNRLRRGP LTFTTRTVRQ VFRLEEGVAS DEEAEEAQPG SGPSPEPEGS PPAHPQ 2036 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.