| Tag | Content |
|---|
| CPLM ID | CPLM-016774 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription elongation factor B polypeptide 3 |
Protein Synonyms/Alias | Elongin 110 kDa subunit; Elongin-A; EloA; RNA polymerase II transcription factor SIII subunit A1; SIII p110 |
Gene Name | Tceb3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 430 | SSTALGEKGLKKKDS | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). |
Sequence Annotation | DOMAIN 4 79 TFIIS N-terminal.
DOMAIN 565 609 F-box.
REGION 521 680 Activation domain (By similarity).
REGION 549 558 Interacting with Elongin BC complex (By
MOD_RES 82 82 Phosphoserine.
MOD_RES 195 195 Phosphoserine.
MOD_RES 309 309 Phosphoserine.
MOD_RES 379 379 Phosphoserine (By similarity).
MOD_RES 390 390 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 773 AA |
Protein Sequence | MAAESALQVV EKLQARLAAN PDPKKLLKYL KKLSILPITV DILVETGVGK TVNSFRKHEQ 60
VGNFARDLVA QWKKLVPVER NSEAEDQDFE KNNSRKRPRD ALQREEELEG NYQESWKPSG 120
SRSYSPEHRQ KKHKKLSEPE RPHKVAHSHE KRDERKRCHK VSPPYSSDPE SSDYGHVQSP 180
PPSSPHQMYT DLSRSPEEDQ EPIISHQKPG KVHSNTFQDR LGVSHLGEQG KGAVSHHKQH 240
RSSHKEKHPA DAREDEKISA VSREKSHKAS SKEESRRLLS GDSAKEKLPS SVVKKDKDRE 300
GSSLKKKFSP ALDVASDNHF KKPKHKDSEK AKSDKNKQSV DGVDSGRGTG DPLPKAKEKV 360
PNHLKAQEGK VRTNADGKSA GPLHPKAEET DVDDEFERPT MSFESYLSYD QPRKKKKKVV 420
KTSSTALGEK GLKKKDSKST SKNLNSAQKL PKVNENKSEK LQPAGAEPTR PRKVPTDVLP 480
ALPDIPLPAI HANYRPLPSL ELIPSFQPKR KAFSSPQEEE EAGFTGRRMN SKMQVYSGSK 540
CAYLPKMMTL HQQCIRVLKN NIDSIFEVGG VPYSVLEPVL ERCTPDQLYR IEECNHVLIE 600
ETDQLWKVHC HRDFKEERPE EYESWREMYL RLQDAREQRL RLLTNNIRSA HANKPKGRQA 660
KMAFVNSVAK PPRDVRRRQE KFGTGGAAVP EKVRIKPAPY TTGSSHVPAS NSSSNFHSSP 720
EELAYDGPST SSAHLAPVAS SSVSYDPRKP AVKKIAPMMA KTIKAFKNRF SRR 773 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:InterPro. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |