UniProt Accession

 PLF4_RAT; P06765 

Genbank Protein ID

 M15254 

Genbank Nucleotide ID

 AAA41832.1 

Protein Name

 Platelet factor 4 

Protein Synonyms/Alias

 PF-4; C-X-C motif chemokine 4 

Gene Name

 Pf4 

Gene Synonyms/Alias

 Cxcl4; Scyb4 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
96	DRQVPLYKKIIKKLL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. 

Sequence Annotation

 REGION 96 102 Heparin-binding (By similarity).
 CARBOHYD 31 31 O-linked (GalNAc...); partial.
 DISULFID 44 71 By similarity.
 DISULFID 46 87 By similarity.  

Keyword

 Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Heparin-binding; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0031091; C:platelet alpha granule; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0008201; F:heparin binding; ISS:UniProtKB.
 GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.
 GO:0006955; P:immune response; IDA:RGD.
 GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.
 GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
 GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB.
 GO:0030168; P:platelet activation; ISS:UniProtKB.
 GO:0006461; P:protein complex assembly; IPI:RGD. 

Interpro

 IPR001089; Chemokine_CXC.
 IPR018048; Chemokine_CXC_CS.
 IPR001811; Chemokine_IL8-like_dom.
 IPR027222; PF4. 

Pfam

 PF00048; IL8 

SMART

 SM00199; SCY 

PROSITE

 PS00471; SMALL_CYTOKINES_CXC 

PRINTS

 PR00437; SMALLCYTKCXC.