CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012287
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynactin subunit 1 
Protein Synonyms/Alias
 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued 
Gene Name
 DCTN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
999LPPLHVAKLSHEGPGubiquitination[1]
1017PAGALYRKTSQLLETubiquitination[1]
1045TRTSPAAKSPSAQLMubiquitination[1]
1059MEQVAQLKSLSDTVEubiquitination[1]
1101SSAFLRAKEEQQDDTubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. 
Sequence Annotation
 DOMAIN 48 90 CAP-Gly.
 MOD_RES 108 108 Phosphothreonine.
 MOD_RES 541 541 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Neurodegeneration; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1278 AA 
Protein Sequence
MMRQAPTARK TTTRRPKPTR PASTGVAGAS SSLGPSGSAS AGELSSSEPS TPAQTPLAAP 60
IIPTPVLTSP GAVPPLPSPS KEEEGLRAQV RDLEEKLETL RLKRAEDKAK LKELEKHKIQ 120
LEQVQEWKSK MQEQQADLQR RLKEARKEAK EALEAKERYM EEMADTADAI EMATLDKEMA 180
EERAESLQQE VEALKERVDE LTTDLEILKA EIEEKGSDGA ASSYQLKQLE EQNARLKDAL 240
VRMRDLSSSE KQEHVKLQKL MEKKNQELEV VRQQRERLQE ELSQAESTID ELKEQVDAAL 300
GAEEMVEMLT DRNLNLEEKV RELRETVGDL EAMNEMNDEL QENARETELE LREQLDMAGA 360
RVREAQKRVE AAQETVADYQ QTIKKYRQLT AHLQDVNREL TNQQEASVER QQQPPPETFD 420
FKIKFAETKA HAKAIEMELR QMEVAQANRH MSLLTAFMPD SFLRPGGDHD CVLVLLLMPR 480
LICKAELIRK QAQEKFELSE NCSERPGLRG AAGEQLSFAA GLVYSLSLLQ ATLHRYEHAL 540
SQCSVDVYKK VGSLYPEMSA HERSLDFLIE LLHKDQLDET VNVEPLTKAI KYYQHLYSIH 600
LAEQPEDCTM QLADHIKFTQ SALDCMSVEV GRLRAFLQGG QEATDIALLL RDLETSCSDI 660
RQFCKKIRRR MPGTDAPGIP AALAFGPQVS DTLLDCRKHL TWVVAVLQEV AAAAAQLIAP 720
LAENEGLLVA ALEELAFKAS EQIYGTPSSS PYECLRQSCN ILISTMNKLA TAMQEGEYDA 780
ERPPSKPPPV ELRAAALRAE ITDAEGLGLK LEDRETVIKE LKKSLKIKGE ELSEANVRLS 840
LLEKKLDSAA KDADERIEKV QTRLEETQAL LRKKEKEFEE TMDALQADID QLEAEKAELK 900
QRLNSQSKRT IEGLRGPPPS GIATLVSGIA GEEQQRGAIP GQAPGSVPGP GLVKDSPLLL 960
QQISAMRLHI SQLQHENSIL KGAQMKASLA SLPPLHVAKL SHEGPGSELP AGALYRKTSQ 1020
LLETLNQLST HTHVVDITRT SPAAKSPSAQ LMEQVAQLKS LSDTVEKLKD EVLKETVSQR 1080
PGATVPTDFA TFPSSAFLRA KEEQQDDTVY MGKVTFSCAA GFGQRHRLVL TQEQLHQLHS 1140
RLIS 1144 
Gene Ontology
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0000776; C:kinetochore; IDA:UniProtKB.
 GO:0005874; C:microtubule; IDA:UniProtKB.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0003774; F:motor activity; IEA:UniProtKB-KW.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007067; P:mitosis; NAS:ProtInc.
 GO:0007399; P:nervous system development; NAS:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR000938; CAP-Gly_domain.
 IPR022157; Dynactin. 
Pfam
 PF01302; CAP_GLY
 PF12455; Dynactin 
SMART
 SM01052; CAP_GLY 
PROSITE
 PS00845; CAP_GLY_1
 PS50245; CAP_GLY_2 
PRINTS