| Tag | Content |
|---|
| CPLM ID | CPLM-011663 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein VAC14 homolog |
Protein Synonyms/Alias | Tax1-binding protein 2 |
Gene Name | VAC14 |
Gene Synonyms/Alias | TAX1BP2; TRX |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MNPEKDFAPLTP | ubiquitination | [1] | | 70 | SQHPHSRKGGLIGLA | ubiquitination | [1] | | 151 | ADPDPNVKSGSELLD | ubiquitination | [1] | | 318 | DDRKKSIKEVANVCN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. |
Sequence Annotation | REPEAT 5 42 HEAT 1.
REPEAT 89 126 HEAT 2.
REPEAT 171 208 HEAT 3.
REPEAT 212 249 HEAT 4.
REPEAT 438 475 HEAT 5.
REPEAT 560 598 HEAT 6.
REGION 773 777 Mediates interaction with the PDZ domain
MOD_RES 11 11 Phosphothreonine.
MOD_RES 499 499 Phosphothreonine. |
Keyword | Complete proteome; Endoplasmic reticulum; Endosome; Host-virus interaction; Membrane; Microsome; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 782 AA |
Protein Sequence | MNPEKDFAPL TPNIVRALND KLYEKRKVAA LEIEKLVREF VAQNNTVQIK HVIQTLSQEF 60
ALSQHPHSRK GGLIGLAACS IALGKDSGLY LKELIEPVLT CFNDADSRLR YYACEALYNI 120
VKVARGAVLP HFNVLFDGLS KLAADPDPNV KSGSELLDRL LKDIVTESNK FDLVSFIPLL 180
RERIYSNNQY ARQFIISWIL VLESVPDINL LDYLPEILDG LFQILGDNGK EIRKMCEVVL 240
GEFLKEIKKN PSSVKFAEMA NILVIHCQTT DDLIQLTAMC WMREFIQLAG RVMLPYSSGI 300
LTAVLPCLAY DDRKKSIKEV ANVCNQSLMK LVTPEDDELD ELRPGQRQAE PTPDDALPKQ 360
EGTASGGPDG SCDSSFSSGI SVFTAASTER APVTLHLDGI VQVLNCHLSD TAIGMMTRIA 420
VLKWLYHLYI KTPRKMFRHT DSLFPILLQT LSDESDEVIL KDLEVLAEIA SSPAGQTDDP 480
GPLDGPDLQA SHSELQVPTP GRAGLLNTSG TKGLECSPST PTMNSYFYKF MINLLKRFSS 540
ERKLLEVRGP FIIRQLCLLL NAENIFHSMA DILLREEDLK FASTMVHALN TILLTSTELF 600
QLRNQLKDLK TLESQNLFCC LYRSWCHNPV TTVSLCFLTQ NYRHAYDLIQ KFGDLEVTVD 660
FLAEVDKLVQ LIECPIFTYL RLQLLDVKNN PYLIKALYGL LMLLPQSSAF QLLSHRLQCV 720
PNPELLQTED SLKAAPKSQK ADSPSIDYAE LLQHFEKVQN KHLEVRHQRS GRGDHLDRRV 780
VL 782 |
Gene Ontology | GO:0031901; C:early endosome membrane; TAS:Reactome. GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW. GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0031902; C:late endosome membrane; TAS:Reactome. GO:0019209; F:kinase activator activity; IEA:InterPro. GO:0004872; F:receptor activity; NAS:UniProtKB. GO:0006661; P:phosphatidylinositol biosynthetic process; TAS:Reactome. GO:0007165; P:signal transduction; NAS:UniProtKB. GO:0044281; P:small molecule metabolic process; TAS:Reactome. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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