UniProt Accession

 RUVB1_RAT; P60123; O35753 

Genbank Protein ID

 AB002406; AB001581; BC072511; BC086531 

Genbank Nucleotide ID

 BAA20875.1; BAA76313.1; AAH72511.1; AAH86531.1 

Protein Name

 RuvB-like 1 

Protein Synonyms/Alias

 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; Pontin 52; TIP49a 

Gene Name

 Ruvbl1 

Gene Synonyms/Alias

 Tip49; Tip49a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
2	******MKIEEVKST	acetylation	[1]
171	AKGTKQLKLDPSIFE	acetylation	[1]
453	ILADQQDKYMK****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). 

Sequence Annotation

 NP_BIND 70 77 ATP.
 MOD_RES 453 453 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Activator; ATP-binding; Cell cycle; Cell division; Chromatin regulator; Complete proteome; Direct protein sequencing; DNA damage; DNA recombination; DNA repair; Growth regulation; Helicase; Hydrolase; Mitosis; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 456 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0031011; C:Ino80 complex; IEA:Compara.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR027238; RuvB-like.
 IPR010339; TIP49_C. 

Pfam

 PF06068; TIP49 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS