UniProt Accession

 LIN7A_RAT; Q9Z250; Q9Z251 

Genbank Protein ID

 CF978128; AF090134; AF090135 

Genbank Nucleotide ID

 AAC78073.1; AAC78074.1 

Protein Name

 Protein lin-7 homolog A 

Protein Synonyms/Alias

 Lin-7A; Mammalian lin-seven protein 1; MALS-1; Vertebrate lin-7 homolog 1; Veli-1 

Gene Name

 Lin7a 

Gene Synonyms/Alias

 Mals1; Veli1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
91	FRARATAKATVAAFA	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. 

Sequence Annotation

 DOMAIN 25 80 L27.
 DOMAIN 108 190 PDZ.
 MOTIF 14 28 Kinase interacting site (By similarity).  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Exocytosis; Membrane; Postsynaptic cell membrane; Protein transport; Reference proteome; Synapse; Synaptosome; Tight junction; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 232 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IDA:RGD.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0048489; P:synaptic vesicle transport; IEA:Compara. 

Interpro

 IPR004172; L27.
 IPR014775; L27_C.
 IPR017365; Lin-7_homologue.
 IPR001478; PDZ. 

Pfam

 PF02828; L27
 PF00595; PDZ 

SMART

 SM00569; L27
 SM00228; PDZ 

PROSITE

 PS51022; L27
 PS50106; PDZ 

PRINTS