CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038235
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inhibitor of nuclear factor kappa-B kinase subunit epsilon 
Protein Synonyms/Alias
  
Gene Name
 Ikbke 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
130EEGQSIYKLSDFGAAubiquitination[1]
217MYRITTEKPAGAISGubiquitination[1]
486TLSEILSKCSHNVTEubiquitination[1]
507CLGEELLKNRDQIHEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 693 AA 
Protein Sequence
MQSTTNYLWH TDDLLGQGAT ASVYKARNKK SGEVVAVKVF NSASYRRPPE VQGGSRQKVL 60
IMEYCSSGSL LSVLEDPENT FGLSEEEFLV VLRCVVAGMN HLRENGIVHR DIKPGNIMRL 120
VGEEGQSIYK LSDFGAARKL DDDEKFVSVY GTEEYLHPDM YERAVLRKPQ QKAFGVTVDL 180
WSIGVTLYHA ATGSLPFIPF GGPRRNKEIM YRITTEKPAG AISGTQKQEN GPLEWSYSLP 240
ITCRLSMGLQ NQLVPILANI LEVEEDKCWG FDQFFAETSD ILQRTVIHVF SLPQAVLHHV 300
YIHAHNTIAI FLEAVYEQTN VTPKHQEYLF EGHPCVLEPS LSAQHIAHTA ASSPLTLFSM 360
SSDTPKGLAF RDPALDVPKF VPKVDLQADY STAKGVLGAG YQALWLARVL LDGQALMLRG 420
LHWVLEVLQD TCQQTLEVTR TALLYLSSSL GTERFSSGAG MPDVQERKEA TELRTRLQTL 480
SEILSKCSHN VTETQRSLSC LGEELLKNRD QIHEDNKSIQ KIQCCLDKMH FIYKQFKKSR 540
MRPGLSYNEE QIHKLDKVNF SHLAKRLLQV FQEECVQTYQ VSLVTHGKRM RQVQRAQNHL 600
HLIGHSVATC NSEARGAQES LNKIFDQLLL DRASEQGAEV SPQPMAPHPG PDPKDLVFHM 660
QELCNDMKLL AFDLQDNNRL IERLHRVPSA PDV 693 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008384; F:IkappaB kinase activity; IDA:MGI. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 
PRINTS