CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039559
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Adenosine deaminase 
Protein Synonyms/Alias
  
Gene Name
 ADA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9AQTPAFDKPKVELHVacetylation[1]
9AQTPAFDKPKVELHVubiquitination[1, 2, 3]
54LNVIGMDKPLTLPDFubiquitination[3]
90AYEFVEMKAKEGVVYubiquitination[1, 2, 3]
92EFVEMKAKEGVVYVEubiquitination[3]
111PHLLANSKVEPIPWNubiquitination[3]
147GERDFGVKARSILCCubiquitination[1, 2, 3]
164HQPNWSPKVVELCKKacetylation[1]
164HQPNWSPKVVELCKKubiquitination[1, 2, 3]
170PKVVELCKKYQQQTVacetylation[1]
170PKVVELCKKYQQQTVubiquitination[1, 2, 3]
171KVVELCKKYQQQTVVubiquitination[1]
249SYLTGAWKPDTEHAVubiquitination[3]
260EHAVIRLKNDQANYSubiquitination[1, 2, 3, 4]
277TDDPLIFKSTLDTDYubiquitination[1, 3]
288DTDYQMTKRDMGFTEubiquitination[1, 2, 3]
299GFTEEEFKRLNINAAacetylation[1]
299GFTEEEFKRLNINAAubiquitination[1, 2, 3]
307RLNINAAKSSFLPEDubiquitination[1, 2, 3]
316SFLPEDEKRELLDLLubiquitination[1, 2, 3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD 60
FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA 120
EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI 180
DLAGDETIPG SSLLPGHVQA YQAVDILKTE RLGHGYHTLE DQALYNRLRQ ENMHFEICPW 240
SSYLTGAWKP DTEHAVIRLK NDQANYSLNT DDPLIFKSTL DTDYQMTKRD MGFTEEEFKR 300
LNINAAKSSF LPEDEKRELL DLLYKAYGMP PSASAGQNL 339 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0019239; F:deaminase activity; IEA:InterPro.
 GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro. 
Interpro
 IPR006650; A/AMP_deam_AS.
 IPR001365; A/AMP_deaminase_dom. 
Pfam
 PF00962; A_deaminase 
SMART
  
PROSITE
 PS00485; A_DEAMINASE 
PRINTS