| Tag | Content |
|---|
| CPLM ID | CPLM-016921 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Testis-specific H1 histone |
Protein Synonyms/Alias | Haploid germ cell-specific nuclear protein 1; Histone H1t2 |
Gene Name | H1fnt |
Gene Synonyms/Alias | Hanp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 363 | QEPERPVKQTIQKPA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. |
Sequence Annotation | |
Keyword | ATP-binding; Chromosome; Coiled coil; Complete proteome; Developmental protein; Differentiation; DNA condensation; DNA-binding; Nucleotide-binding; Nucleus; Reference proteome; Spermatogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 398 AA |
Protein Sequence | MAEAVQPSGE SQGAELTIQI QQPAERALRT PAKRGTQSVL RVSQLLLRAI AGHQHLTLDA 60
LKKELGNAGY EVRREISSHH EGKSTRLEKG TLLRVSGSDA AGYFRVWKIS KPREKAGQSR 120
LTLGSHSSGK TVLKSPRPLR PRSRRKAAKK AREVWRRKAR ALKARSRRVR TRSTSGARSR 180
TRSRASSRAT SRATSRARSR ARSRAQSSAR SSARSSAKSS AKSSTRSSAK SWARSKARSR 240
ARSRAKDLVR SKAREQAQAR EQARARAREQ AHARARTQDW VRAKAQEFVS AKEQQYVRAK 300
EQERAKAREQ VRIGARDEAR IKAKDYNRVR PTKEDTSPRP AEEKSSNSKL REEKGQEPER 360
PVKQTIQKPA LDNAPSIQGK ACTKSFTKSG QPGDTESP 398 |
Gene Ontology | GO:0000790; C:nuclear chromatin; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003677; F:DNA binding; TAS:UniProtKB. GO:0030261; P:chromosome condensation; TAS:MGI. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0035092; P:sperm chromatin condensation; IMP:UniProtKB. GO:0007290; P:spermatid nucleus elongation; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |