| Tag | Content |
|---|
| CPLM ID | CPLM-012349 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Type I inositol 1,4,5-trisphosphate 5-phosphatase |
Protein Synonyms/Alias | 5PTase |
Gene Name | INPP5A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 73 | SHVDKFVKELLSSDA | ubiquitination | [1, 2] | | 265 | ADTNEVVKLIFRESD | ubiquitination | [1, 2] | | 284 | VMLQLEKKLFDYFNQ | ubiquitination | [1, 2] | | 307 | TALLEFDKELSVFKD | ubiquitination | [1, 2] | | 358 | ILMSPSAKELVLRSE | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. |
Sequence Annotation | MOD_RES 409 409 Cysteine methyl ester (Potential).
LIPID 408 408 S-palmitoyl cysteine (Potential).
LIPID 409 409 S-farnesyl cysteine (Potential). |
Keyword | Complete proteome; Hydrolase; Lipoprotein; Membrane; Methylation; Palmitate; Polymorphism; Prenylation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 412 AA |
Protein Sequence | MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN 60
YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF 120
DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL 180
VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK 240
SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT 300
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL 360
VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ 412 |
Gene Ontology | GO:0005886; C:plasma membrane; TAS:Reactome. GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC. GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC. GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; NAS:UniProtKB. GO:0007154; P:cell communication; NAS:UniProtKB. GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome. GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |