| Tag | Content |
|---|
| CPLM ID | CPLM-009125 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase RNF216 |
Protein Synonyms/Alias | RING finger protein 216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1 |
Gene Name | Rnf216 |
Gene Synonyms/Alias | Triad3; Ubce7ip1; Uip83; Zin |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 407 | IDFFDYSKLTPLDQR | ubiquitination | [1] | | 521 | QALLPAVKQEQEFYE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis (By similarity). |
Sequence Annotation | ZN_FING 503 554 RING-type 1.
ZN_FING 571 636 IBR-type.
ZN_FING 663 702 RING-type 2. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Ligase; Metal-binding; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 853 AA |
Protein Sequence | MAEGNNKEEV IHLNNFPCHR GKEWMAVREG PITISDSSDE EGIPMLVTPA TEQQEDDLDD 60
DVILTETHKP QTSRPNLIKP AAQWQDLNRL GEERPRKSRA DFEADIHNYF SFCNNSLFGS 120
GAQDDSEDEY GGFLDLESGK KEGEAKPGPS SKQTADDIVN PRLEQKVIIL GENGLLFPES 180
EPLEVQNQSS EDSETELLSN PGEPAASVDD QLIGEEYWLD HPYFQAPNPQ PQERTNQVVP 240
QERHSESEMG PMFFRHDFPE PAFPRPEPQQ EGIPGPASPQ PAHPLGELED QQLAIDEDPG 300
PAFPLSGPQE ANLANMWEQE AAEVDQDLIP LLVKETEARF PDVASGYVEE IIHLKNYYDL 360
NVLCNFLLEN PDYPKREDRL IIHPSSSLLA SQDDAKLPKI DFFDYSKLTP LDQRCFIQAA 420
DLLMADFKML SSQDIKWALH ELKGHYAITR KAFSDAIKKW QELSPETSGK RKKRKEMNQY 480
SFIDFKFEQG NIKIEKRMFF LENKRRHCRY YDHQALLPAV KQEQEFYEQK IKEMAEHEDF 540
LLALQMNEEQ YQKDGQLIEC RCCYGEFPFE ELTQCADAHL FCKECLIRYA QEAVFGSGKS 600
ELSCMEGSCT CSFPTSELEK VLPQTILYKY YERKAEEEVA AAYADELVRC PSCSFPALLD 660
SDVKRFSCPN PRCRKETCRK CQGLWKEHNG LTCEELAEKD DIKYRTSIEE KMTAARIRKC 720
HKCGTGLIKS EGCNRMSCRC GAQMCYLCRV SINGYDHFCQ HPRSPGAPCQ ECSRCSLWTD 780
PTEDDEKLIE EIQKEAEEEQ KRKNGENTFK RIGPPLEKPA EKVQRVEALP RPVPQNLHPQ 840
MPPYAFVHPP FPLPPVRPVF NNFPINMGPV PAPYVPPLPN VRVNYDFGHM HVPLEHNLPM 900
HFGPQPRHRF 910 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. GO:0050691; P:regulation of defense response to virus by host; ISS:UniProtKB. GO:0032648; P:regulation of interferon-beta production; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |