| Tag | Content |
|---|
| CPLM ID | CPLM-019262 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | OTU domain-containing protein 5 |
Protein Synonyms/Alias | Deubiquitinating enzyme A; DUBA |
Gene Name | OTUD5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 181 | QQEHWFEKALRDKKG | ubiquitination | [1] | | 327 | GLGLPSFKPGFAEQS | ubiquitination | [1] | | 341 | SLMKNAIKTSEESWI | ubiquitination | [1] | | 356 | EQQMLEDKKRATDWE | ubiquitination | [1] | | 357 | QQMLEDKKRATDWEA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). |
Sequence Annotation | DOMAIN 213 341 OTU.
ACT_SITE 221 221 Potential.
ACT_SITE 224 224 Nucleophile.
ACT_SITE 334 334 Probable.
MOD_RES 64 64 Phosphoserine.
MOD_RES 165 165 Phosphoserine.
MOD_RES 175 175 Phosphotyrosine.
MOD_RES 177 177 Phosphoserine.
MOD_RES 452 452 Phosphoserine.
MOD_RES 507 507 Phosphothreonine.
MOD_RES 508 508 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 571 AA |
Protein Sequence | MTILPKKKPP PPDADPGGTG VGGGDRDRDS GVVGARPRAS PPPQGPLPGP PGALHRWALA 60
VPPGAVAGPR PQQASPPPCG GPGGPGGGPG DALGAAAAGV GAAGVVVGVG GAVGVGGCCS 120
GPGHSKRRRQ APGVGAVGGG SPEREEVGAG YNSEDEYEAA AARIEAMDPA TVEQQEHWFE 180
KALRDKKGFI IKQMKEDGAC LFRAVADQVY GDQDMHEVVR KHCMDYLMKN ADYFSNYVTE 240
DFTTYINRKR KNNCHGNHIE MQAMAEMYNR PVEVYQYSTE PINTFHGIHQ NEDEPIRVSY 300
HRNIHYNSVV NPNKATIGVG LGLPSFKPGF AEQSLMKNAI KTSEESWIEQ QMLEDKKRAT 360
DWEATNEAIE EQVARESYLQ WLRDQEKQAR QVRGPSQPRK ASATCSSATA AASSGLEEWT 420
SRSPRQRSSA SSPEHPELHA ELGMKPPSPG TVLALAKPPS PCAPGTSSQF SAGADRATSP 480
LVSLYPALEC RALIQQMSPS AFGLNDWDDD EILASVLAVS QQEYLDSMKK NKVHRDPPPD 540
KS 542 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB. GO:0045087; P:innate immune response; TAS:Reactome. GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome. GO:0071108; P:protein K48-linked deubiquitination; IDA:UniProtKB. GO:0070536; P:protein K63-linked deubiquitination; IDA:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |