CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012861
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 4-kinase type 2-alpha 
Protein Synonyms/Alias
 Phosphatidylinositol 4-kinase type II-alpha 
Gene Name
 Pi4k2a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
141SSGSYFVKDSQGRIVubiquitination[1]
240GKRLALEKVPKVGQRubiquitination[1]
341MVREPVIKVAAIDNGubiquitination[1]
354NGLAFPLKHPDSWRAubiquitination[1]
435LNLTQALKDNKSPLHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). 
Sequence Annotation
 DOMAIN 133 438 PI3K/PI4K.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 9 9 Phosphoserine (By similarity).
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 462 462 Phosphoserine.
 MOD_RES 464 464 Phosphoserine (By similarity).  
Keyword
 Acetylation; ATP-binding; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endosome; Kinase; Membrane; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MDETSPLVSP ERAQPPEYTF PSGSGAHFPQ VPGGAVRVAA AAGSGPSPPC SPGHDRERQP 60
LLDRARGAAA QGQTHTVAVQ AQALAAQAAV AAHAVQTHRE RNDFPEDPEF EVVVRQAEVA 120
IECSIYPERI YQGSSGSYFV KDSQGRIVAV FKPKNEEPYG HLNPKWTKWL QKLCCPCCFG 180
RDCLVLNQGY LSEAGASLVD QKLELNIVPR TKVVYLASET FNYSAIDRVK SRGKRLALEK 240
VPKVGQRFNR IGLPPKVGSF QLFVEGYKDA DYWLRRFEAE PLPENTNRQL LLQFERLVVL 300
DYIIRNTDRG NDNWLIKYDC PMDNSSCRDT DWVMVREPVI KVAAIDNGLA FPLKHPDSWR 360
AYPFYWAWLP QAKVPFSQEI KDLILPKISD PNFIKDLEED LYELFKRDPG FDRGQFHKQI 420
AVMRGQILNL TQALKDNKSP LHLVQMPPVI VETARSHQRS ASESYTQSFQ SRKPFFSWW 479 
Gene Ontology
 GO:0031083; C:BLOC-1 complex; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
 GO:0030425; C:dendrite; IDA:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:Compara.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0070382; C:exocytic vesicle; IEA:Compara.
 GO:0035838; C:growing cell tip; ISS:UniProtKB.
 GO:0044231; C:host cell presynaptic membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0043025; C:neuronal cell body; IDA:UniProtKB.
 GO:0043204; C:perikaryon; IEA:Compara.
 GO:0042734; C:presynaptic membrane; IDA:UniProtKB.
 GO:0030672; C:synaptic vesicle membrane; IEA:Compara.
 GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:EC.
 GO:0035651; F:AP-3 adaptor complex binding; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0002561; P:basophil degranulation; IEA:Compara.
 GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:Compara. 
Interpro
 IPR000403; PI3/4_kinase_cat_dom. 
Pfam
 PF00454; PI3_PI4_kinase 
SMART
  
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS