UniProt Accession

 ZWINT_RAT; Q8VIL3; Q546Y5 

Genbank Protein ID

 AF439397; AF532776; BC063144 

Genbank Nucleotide ID

 AAL35221.1; AAM95974.1; AAH63144.1 

Protein Name

 ZW10 interactor 

Protein Synonyms/Alias

 SNAP25-interacting protein 30; Scoilin; ZW10-interacting protein 1; Zwint-1 

Gene Name

 Zwint 

Gene Synonyms/Alias

 Sip30 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MADAEKNAVAEKN	acetylation	[1]
163	AFEQLEAKKRVLEEK	ubiquitination	[2]
176	EKLQLAQKQWVLQQK	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity). 

Sequence Annotation

 REGION 86 161 Interaction with NDC80 and ZW10 (By  

Keyword

 Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Direct protein sequencing; Kinetochore; Mitosis; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051649; P:establishment of localization in cell; IEA:Compara.
 GO:0007093; P:mitotic cell cycle checkpoint; IEA:Compara.
 GO:0000070; P:mitotic sister chromatid segregation; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS