UniProt Accession

 LRSM1_HUMAN; Q6UWE0; Q5VVV0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7 

Genbank Protein ID

 AY358830; AK056203; AK056305; AK091589; AL445222; AL445222; BC009239 

Genbank Nucleotide ID

 AAQ89189.1; BAB71119.1; BAB71144.1; BAC03703.1; CAH72930.1; CAH72931.1; AAH09239.1 

Protein Name

 E3 ubiquitin-protein ligase LRSAM1 

Protein Synonyms/Alias

 Leucine-rich repeat and sterile alpha motif-containing protein 1; Tsg101-associated ligase; hTAL 

Gene Name

 LRSAM1 

Gene Synonyms/Alias

 TAL; UNQ6496/PRO21356 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	QLTQLELKRKSLDTE	ubiquitination	[1]
100	SLLQQLLKEKQQREE	ubiquitination	[1]
220	ARIQPELKPPMGEVV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. 

Sequence Annotation

 REPEAT 30 51 LRR 1.
 REPEAT 56 77 LRR 2.
 REPEAT 82 103 LRR 3.
 REPEAT 105 127 LRR 4.
 REPEAT 128 149 LRR 5.
 REPEAT 151 172 LRR 6.
 DOMAIN 569 632 SAM.
 ZN_FING 675 710 RING-type.
 MOTIF 649 652 PTAP motif 1.
 MOTIF 661 664 PTAP motif 2.
 MOD_RES 234 234 Phosphoserine.
 MOD_RES 604 604 Phosphoserine.  

Keyword

 Alternative splicing; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Leucine-rich repeat; Ligase; Metal-binding; Neuropathy; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 723 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0044425; C:membrane part; IDA:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045806; P:negative regulation of endocytosis; IMP:UniProtKB.
 GO:0046755; P:non-lytic virus budding; IMP:UniProtKB.
 GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
 GO:0030163; P:protein catabolic process; IMP:UniProtKB.
 GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0070086; P:ubiquitin-dependent endocytosis; IDA:UniProtKB. 

Interpro

 IPR016179; Insulin-like.
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR011510; SAM_2.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12799; LRR_4
 PF07647; SAM_2 

SMART

 SM00078; IlGF
 SM00184; RING
 SM00454; SAM 

PROSITE

 PS51450; LRR
 PS50105; SAM_DOMAIN
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS