UniProt Accession

 ARI1_YEAST; P53111; D6VTZ4 

Genbank Protein ID

 Z48618; Z72679; BK006941 

Genbank Nucleotide ID

 CAA96869.1; DAA07955.1 

Protein Name

 NADPH-dependent aldehyde reductase ARI1 

Protein Synonyms/Alias

  

Gene Name

 ARI1 

Gene Synonyms/Alias

 YGL157W; G1857 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
40	GSGRSQEKNDGLLKK	acetylation	[1]
308	TGPSFLEKNSCKFDN	ubiquitination	[2]
320	FDNSKTKKLLGFQFY	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 NADPH-dependent aldehyde reductase involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Reduces commonly detected inhibitors in biomass conversion hydrolysates such as furfural, 5- hydroxymethylfurfural (HMF), cinnamic aldehyde, benzaldehyde, phenylacetaldehyde, and anisaldehyde. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; NADP; Nucleus; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004090; F:carbonyl reductase (NADPH) activity; IDA:SGD.
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0044237; P:cellular metabolic process; IEA:InterPro. 

Interpro

 IPR001509; Epimerase_deHydtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01370; Epimerase 

SMART

  

PROSITE

  

PRINTS